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Tbio
PEG3
Paternally-expressed gene 3 protein

Protein Summary
Description
Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells. In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326441
  • ENSP00000326581
  • ENSG00000198300
  • ENST00000593695
  • ENSP00000472402
  • ENST00000598410
  • ENSP00000473190
  • ENST00000599534
  • ENSP00000472395
  • ENST00000599577
  • ENSP00000469486
  • ENST00000648694
  • ENSP00000496914
  • ENST00000649233
  • ENSP00000498047
  • ENST00000649428
  • ENSP00000498138
  • ENST00000649680
  • ENSP00000497512
  • ENST00000649876
  • ENSP00000496867
  • ENST00000650102
  • ENSP00000497466
  • ENST00000650632
  • ENSP00000497971

Symbol
  • KIAA0287
  • ZSCAN24
  • PW1
  • ZNF904
  • ZSCAN24
  • ZKSCAN22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.92
transcription factor perturbation
0.88
protein domain
0.85
interacting protein
0.8
cell line
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 273.8   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 273.8   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
GRB10
Tbio
Novelty:  0.00762794
Score:  0.798
Data Source:  STRINGDB
SNRPN
Tbio
Novelty:  0.002157
Score:  0.789
Data Source:  STRINGDB
MEST
Tbio
Family:  Enzyme
Novelty:  0.00226252
Score:  0.749
Data Source:  STRINGDB
PEG10
Tbio
Novelty:  0.00478545
Score:  0.72
Data Source:  STRINGDB
PLAGL1
Tbio
Family:  TF
Novelty:  0.00845226
Score:  0.714
Data Source:  STRINGDB
NNAT
Tbio
Novelty:  0.01079637
Score:  0.679
Data Source:  STRINGDB
IGF2
Tbio
Novelty:  0.00021277
Score:  0.678
Data Source:  STRINGDB
P63092
Tbio
Novelty:  0.00284739
Score:  0.663
Data Source:  STRINGDB
O95467
Tbio
Novelty:  0.00284739
Score:  0.663
Data Source:  STRINGDB
Q5JWF2
Tbio
Novelty:  0.00284739
Score:  0.663
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
paternally expressed 3
VGNC:2291
469030
Mouse
MGI:104748
18616
Rat
RGD:2323590
103691034
Dog
paternally expressed 3
VGNC:44413
476371
Horse
paternally expressed 3
VGNC:21304
100051103
Species
Name
OMA
EggNOG
Inparanoid
Chimp
paternally expressed 3
Mouse
Rat
Dog
paternally expressed 3
Horse
paternally expressed 3
Publication Statistics
PubMed Score 273.80
PubMed score by year
PubTator Score 117.88
PubTator score by year
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Related Publications
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PMID
Year
Title