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Tchem
PEAK1
Inactive tyrosine-protein kinase PEAK1

Protein Summary
Description
Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics (PubMed:23105102, PubMed:20534451). Acts as a scaffold for mediating EGFR signaling (PubMed:23846654). This gene encodes a non-receptor tyrosine kinase that is a member of the new kinase family three (NFK3) family. In migrating cells, the encoded protein is associated with the actin cytoskeleton and focal adhesions and promotes developing focal adhesion elongation. This protein may play a role in the regulation of cell migration, proliferation and cancer metastasis. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312493
  • ENSP00000309230
  • ENSG00000173517
  • ENST00000560626
  • ENSP00000452796

Symbol
  • KIAA2002
  • SGK269
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
kinase perturbation
0.88
transcription factor binding site profile
0.83
histone modification site profile
0.81
cell type or tissue
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.72   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.72   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (43)
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.999999796
p_ni:  2.04e-7
Score:  0.287
Data Source:  BioPlex,STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
p_int:  0.999999661
p_ni:  3.39e-7
Score:  0.247
Data Source:  BioPlex,STRINGDB
GRB2
Tchem
Novelty:  0.00091605
p_int:  0.999989396
p_ni:  0.000010604
Score:  0.79
Data Source:  BioPlex,STRINGDB
NCK2
Tbio
Novelty:  0.02220251
p_int:  0.999863691
p_ni:  0.000136309
Score:  0.183
Data Source:  BioPlex,STRINGDB
SHC1
Tchem
Novelty:  0.00083615
p_int:  0.999111626
p_ni:  0.000888374
Score:  0.44
Data Source:  BioPlex,STRINGDB
MMP13
Tchem
Family:  Enzyme
Novelty:  0.00057893
p_int:  0.997177393
p_ni:  0.002822606
p_wrong:  1e-9
Data Source:  BioPlex
VWA5A
Tbio
Novelty:  0.0802354
p_int:  0.993697166
p_ni:  0.006302834
Data Source:  BioPlex
BBS7
Tbio
Novelty:  0.03611111
p_int:  0.987489514
p_ni:  0.012510486
Data Source:  BioPlex
AURKA
Tchem
Family:  Kinase
Novelty:  0.0010868
p_int:  0.953189277
p_ni:  0.046810723
Data Source:  BioPlex
CARD8
Tbio
Family:  Enzyme
Novelty:  0.0146799
p_int:  0.900981035
p_ni:  0.099018965
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
5
4
1.1
97.9
neutrophil count
2
2
2
72.4
BMI-adjusted hip circumference
2
5
6
66.8
myeloid white cell count
1
1
1
59.9
vitamin D measurement
3
1
3
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
97.9
neutrophil count
2
72.4
BMI-adjusted hip circumference
6
66.8
myeloid white cell count
1
59.9
vitamin D measurement
3
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pseudopodium enriched atypical kinase 1
VGNC:6466
453767
Mouse
MGI:2442366
244895
Rat
RGD:1312026
315686
Dog
pseudopodium enriched atypical kinase 1
VGNC:44407
487662
Horse
pseudopodium enriched atypical kinase 1
VGNC:21297
100061184
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pseudopodium enriched atypical kinase 1
Mouse
Rat
Dog
pseudopodium enriched atypical kinase 1
Horse
pseudopodium enriched atypical kinase 1
Publication Statistics
PubMed Score 41.72
PubMed score by year
PubTator Score 193.29
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title