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Tbio
PDZD8
PDZ domain-containing protein 8

Protein Summary
Description
Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes (PubMed:29097544). PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer (PubMed:29097544). In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons (PubMed:29097544). Plays an indirect role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). May inhibit herpes simplex virus 1 infection at an early stage (PubMed:21549406).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334464
  • ENSP00000334642
  • ENSG00000165650

Symbol
  • PDZK8
  • PDZK8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
interacting protein
0.81
metabolite
0.71
cell type or tissue
0.7
cell line
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.53   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.53   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
ZNRF4
Tbio
Novelty:  0.16505328
p_int:  0.999899569
p_ni:  0.000100431
Data Source:  BioPlex
PCDHGB2
Tdark
Novelty:  1.16587709
p_int:  0.999553362
p_ni:  0.000446638
Data Source:  BioPlex
LAGE3
Tdark
Novelty:  0.02099961
p_int:  0.999154832
p_ni:  0.000845168
Data Source:  BioPlex
PCDHB16
Tdark
Novelty:  0.67206411
p_int:  0.998995161
p_ni:  0.001004839
Data Source:  BioPlex
PCDHGA5
Tdark
Novelty:  2.13631603
p_int:  0.998541904
p_ni:  0.001458096
Data Source:  BioPlex
CNGA3
Tchem
Family:  IC
Novelty:  0.00818181
p_int:  0.997607927
p_ni:  0.002392073
Data Source:  BioPlex
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
p_int:  0.997444563
p_ni:  0.002555437
Data Source:  BioPlex
KCNS3
Tclin
Family:  IC
Novelty:  0.05882087
p_int:  0.997000715
p_ni:  0.002999285
Data Source:  BioPlex
SRPRB
Tbio
Novelty:  0.04735362
p_int:  0.995100943
p_ni:  0.004899057
Data Source:  BioPlex
EVA1C
Tbio
Novelty:  0.45928677
p_int:  0.992047685
p_ni:  0.007952315
Score:  0.221
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist circumference
1
1
1
7.9
waist-hip ratio
2
1
2
7.3
BMI-adjusted waist-hip ratio
1
1
1
7.3
1
1
0
506.9
4.5
traffic air pollution measurement
1
1
0
506.9
4.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist circumference
1
7.9
waist-hip ratio
2
7.3
BMI-adjusted waist-hip ratio
1
7.3
0
506.9
4.5
traffic air pollution measurement
0
506.9
4.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PDZ domain containing 8
VGNC:5621
450766
Mouse
MGI:2677270
107368
Rat
RGD:1308622
308000
Dog
PDZ domain containing 8
VGNC:44402
486909
Horse
PDZ domain containing 8
VGNC:21291
100067136
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PDZ domain containing 8
Mouse
Rat
Dog
PDZ domain containing 8
Horse
PDZ domain containing 8
Publication Statistics
PubMed Score 14.53
PubMed score by year
PubTator Score 5.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title