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Tbio
PDZD7
PDZ domain-containing protein 7

Protein Summary
Description
In cochlear developing hair cells, essential in organizing the USH2 complex at stereocilia ankle links. Blocks inhibition of adenylate cyclase activity mediated by ADGRV1. This gene encodes a ciliary protein homologous to proteins which are mutated in Usher syndrome patients, and mutations and translocations involving this gene have been associated with two types of Usher syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370215
  • ENSP00000359234
  • ENSG00000186862
  • ENST00000433616
  • ENSP00000412533
  • ENST00000619208
  • ENSP00000480489

Symbol
  • PDZK7
  • PDZK7
  • DFNB57
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.7
transcription factor
0.67
tissue sample
0.61
cell line
0.56
histone modification site profile
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.94   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 52   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.94   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 52   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
USH2A
Tbio
Novelty:  0.00223387
Score:  0.925
Data Source:  STRINGDB
MYO7A
Tbio
Novelty:  0.00314435
Score:  0.857
Data Source:  STRINGDB
CLRN1
Tbio
Novelty:  0.03334995
Score:  0.834
Data Source:  STRINGDB
USH1G
Tbio
Novelty:  0.02912203
Score:  0.831
Data Source:  STRINGDB
ADGRV1
Tbio
Family:  GPCR
Novelty:  0.01398129
Score:  0.814
Data Source:  STRINGDB
ANKK1
Tbio
Family:  Kinase
Novelty:  0.00561173
Score:  0.803
Data Source:  STRINGDB
CIB2
Tbio
Novelty:  0.03578691
Score:  0.769
Data Source:  STRINGDB
CDH23
Tbio
Novelty:  0.00588227
Score:  0.758
Data Source:  STRINGDB
PCDH15
Tbio
Novelty:  0.0097699
Score:  0.737
Data Source:  STRINGDB
MYO7B
Tbio
Novelty:  0.10660261
Score:  0.661
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
3
1
3
91.6
mitochondrial DNA measurement
1
1
1
83.7
mitochondrial heteroplasmy measurement
1
1
1
70.6
refractive error
3
1
2
5.5
61.4
educational attainment
1
1
1
58.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
3
91.6
mitochondrial DNA measurement
1
83.7
mitochondrial heteroplasmy measurement
1
70.6
refractive error
2
5.5
61.4
educational attainment
1
58.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:3608325
100503041
Rat
RGD:1309882
293996
Dog
PDZ domain containing 7
VGNC:53008
486847
Opossum
PDZ domain containing 7
100029768
Chicken
PDZ domain containing 7
CGNC:14297
428974
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
PDZ domain containing 7
Opossum
PDZ domain containing 7
Chicken
PDZ domain containing 7
Publication Statistics
PubMed Score 14.94
PubMed score by year
PubTator Score 5.89
PubTator score by year
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Related Publications
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PMID
Year
Title