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Tbio
PDZD3
Na(+)/H(+) exchange regulatory cofactor NHE-RF4

Protein Summary
Description
Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (PubMed:11950846). Stimulates SLC9A3 activity in the presence of elevated calcium ions (PubMed:19088451). Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322712
  • ENSP00000327107
  • ENSG00000172367
  • ENST00000355547
  • ENSP00000347742
  • ENST00000531114
  • ENSP00000431164

Symbol
  • IKEPP
  • NHERF4
  • PDZK2
  • IKEPP
  • PDZK2
  • NHERF4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.74
tissue
0.67
PubMedID
0.58
biological process
0.54
cellular component
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.02   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.02   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (30)
GUCY2C
Tclin
Family:  Kinase
Novelty:  0.00209733
Score:  0.87
Data Source:  STRINGDB
SLC34A1
Tchem
Family:  Transporter
Novelty:  0.00805088
Score:  0.768
Data Source:  STRINGDB
SLC9A3
Tclin
Family:  Transporter
Novelty:  0.00146466
Score:  0.758
Data Source:  STRINGDB
GUCA2B
Tbio
Family:  Enzyme
Novelty:  0.02002363
Score:  0.69
Data Source:  STRINGDB
CFTR
Tclin
Family:  IC
Novelty:  0.00012639
Score:  0.681
Data Source:  STRINGDB
P2RY4
Tchem
Family:  GPCR
Novelty:  0.00903213
Score:  0.667
Data Source:  STRINGDB
GUCA2A
Tbio
Novelty:  0.00856211
Score:  0.661
Data Source:  STRINGDB
SLC26A3
Tbio
Family:  Transporter
Novelty:  0.00157687
Score:  0.643
Data Source:  STRINGDB
TRPV6
Tchem
Family:  IC
Novelty:  0.00383629
Score:  0.625
Data Source:  STRINGDB
MAPKAPK5
Tchem
Family:  Kinase
Novelty:  0.01349079
Score:  0.589
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Infectious disease
Reactome
Intestinal infectious diseases
Reactome
Uptake and actions of bacterial toxins
Name
Explore in Pharos
Explore in Source
Disease
Infectious disease
Intestinal infectious diseases
Uptake and actions of bacterial toxins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
5
6
6.3
98.8
platelet crit
2
4
5
97.4
mean reticulocyte volume
1
2
2
94.6
lymphocyte count
3
3
3
88.2
mean corpuscular volume
1
2
2
81
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
6
6.3
98.8
platelet crit
5
97.4
mean reticulocyte volume
2
94.6
lymphocyte count
3
88.2
mean corpuscular volume
2
81
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PDZ domain containing 3
VGNC:1089
466803
Macaque
PDZ domain containing 3
704100
Mouse
MGI:2429554
170761
Rat
RGD:1559807
500986
Dog
PDZ domain containing 3
VGNC:44400
610585
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PDZ domain containing 3
Macaque
PDZ domain containing 3
Mouse
Rat
Dog
PDZ domain containing 3
Publication Statistics
PubMed Score 10.02
PubMed score by year
PubTator Score 7.85
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title