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Tbio
PDYN
Proenkephalin-B

Protein Summary
Description
Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity). Leumorphin has a typical opiod activity and may have anti-apoptotic effect. The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217305
  • ENSP00000217305
  • ENSG00000101327
  • ENST00000539905
  • ENSP00000440185
  • ENST00000540134
  • ENSP00000442259

Symbol
  • ADCA
  • PENKB
  • SCA23
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.84
biological term
0.71
PubMedID
0.69
gene perturbation
0.66
chemical
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2716.84   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 229   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2716.84   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (364)
ACAD11
Tbio
Family:  Enzyme
Novelty:  0.22908145
p_int:  0.999707951
p_ni:  0.000292049
Score:  0.167
Data Source:  BioPlex,STRINGDB
LCN1
Tbio
Novelty:  0.00510137
p_int:  0.997820161
p_ni:  0.000155337
p_wrong:  0.002024502
Score:  0.311
Data Source:  BioPlex,STRINGDB
TIMM8B
Tbio
Family:  Enzyme
Novelty:  0.02843625
p_int:  0.994811707
p_ni:  0.005188292
p_wrong:  1e-9
Score:  0.54
Data Source:  BioPlex,STRINGDB
TIMM13
Tdark
Family:  Enzyme
Novelty:  0.04802297
p_int:  0.986451582
p_ni:  0.013548418
Score:  0.513
Data Source:  BioPlex,STRINGDB
OPRM1
Tclin
Family:  GPCR
Novelty:  0.0003701
Score:  0.994
Data Source:  Reactome,STRINGDB
OPRK1
Tclin
Family:  GPCR
Novelty:  0.00171044
Score:  0.992
Data Source:  STRINGDB
OPRD1
Tclin
Family:  GPCR
Novelty:  0.00757692
Score:  0.992
Data Source:  STRINGDB
OPRL1
Tchem
Family:  GPCR
Novelty:  0.00186729
Score:  0.992
Data Source:  STRINGDB
POMC
Tbio
Novelty:  0.00002436
Score:  0.986
Data Source:  STRINGDB
PNOC
Tbio
Novelty:  0.00132014
Score:  0.979
Data Source:  STRINGDB
Pathways (17)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
G-protein activation
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
G-protein activation
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
5
4
7
99.2
platelet count
6
6
6
90.2
platelet crit
2
4
5
89.5
lymphocyte count
4
3
4
89.1
lymphocyte percentage of leukocytes
2
1
2
73.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
7
99.2
platelet count
6
90.2
platelet crit
5
89.5
lymphocyte count
4
89.1
lymphocyte percentage of leukocytes
2
73.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prodynorphin
VGNC:6231
469860
Macaque
prodynorphin
716341
Mouse
MGI:97535
18610
Rat
RGD:62054
29190
Dog
prodynorphin
VGNC:44398
485808
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prodynorphin
Macaque
prodynorphin
Mouse
Rat
Dog
prodynorphin
Publication Statistics
PubMed Score 2716.84
PubMed score by year
PubTator Score 552.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title