Tbio PDXP Pyridoxal phosphate phosphatase

Protein Summary

Description

Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho-tyrosine (PubMed:15580268). Pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP (PubMed:14522954). Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis. The preferred degradation route from PLP to 4-pyridoxic acid involves the dephosphorylation of PLP by PDXP (Jang et al., 2003 [PubMed 14522954]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q96GD0
• Q9UGY2
• PLP phosphatase

Gene Name

• PDXP

Ensembl ID

• ENST00000215904
• ENSP00000215904
• ENSG00000241360

Symbol

• CIN
• PLP
• PLPP
• CIN
• PLP
• dJ37E16.5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.76
biological process	0.75
transcription factor binding site profile	0.65
transcription factor	0.59
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Pyridoxal Phosphate Phosphatase

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Pyridoxal Phosphate Phosphatase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 296.76   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 98   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 296.76   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0