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Tbio
PDXP
Pyridoxal phosphate phosphatase

Protein Summary
Description
Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho-tyrosine (PubMed:15580268). Pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP (PubMed:14522954). Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis. The preferred degradation route from PLP to 4-pyridoxic acid involves the dephosphorylation of PLP by PDXP (Jang et al., 2003 [PubMed 14522954]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215904
  • ENSP00000215904
  • ENSG00000241360

Symbol
  • CIN
  • PLP
  • PLPP
  • CIN
  • PLP
  • dJ37E16.5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.76
biological process
0.75
transcription factor binding site profile
0.65
transcription factor
0.59
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 296.76   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 296.76   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
PNPO
Tchem
Family:  Enzyme
Novelty:  0.00919993
Score:  0.942
Data Source:  STRINGDB
PDXK
Tbio
Family:  Kinase
Novelty:  0.00976418
Score:  0.939
Data Source:  STRINGDB
AOX1
Tchem
Family:  Enzyme
Novelty:  0.0025823
Score:  0.901
Data Source:  STRINGDB
CFL1
Tbio
Novelty:  0.00071544
Score:  0.808
Data Source:  STRINGDB
PHOSPHO2
Tbio
Family:  Enzyme
Novelty:  0.36911271
Score:  0.802
Data Source:  STRINGDB
LIMK1
Tchem
Family:  Kinase
Novelty:  0.00349854
Score:  0.721
Data Source:  STRINGDB
SSH1
Tbio
Family:  Enzyme
Novelty:  0.02079383
Score:  0.665
Data Source:  STRINGDB
PROZ
Tbio
Family:  Enzyme
Novelty:  0.05629679
Score:  0.659
Data Source:  STRINGDB
PSME3
Tbio
Novelty:  0.01051254
Score:  0.648
Data Source:  STRINGDB
TESK1
Tchem
Family:  Kinase
Novelty:  0.06769478
Score:  0.561
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age-related hearing impairment
2
1
1
1.1
76.8
blood protein measurement
1
1
1
71.4
brain measurement
1
1
0
11.7
70.6
serum albumin measurement
2
2
2
67.9
lateral ventricle volume measurement
1
1
0
6.5
67.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age-related hearing impairment
1
1.1
76.8
blood protein measurement
1
71.4
brain measurement
0
11.7
70.6
serum albumin measurement
2
67.9
lateral ventricle volume measurement
0
6.5
67.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pyridoxal phosphatase
VGNC:6705
100615101
Mouse
MGI:1919282
57028
Rat
RGD:1586212
727679
Dog
pyridoxal phosphatase
VGNC:44397
100688635
Horse
pyridoxal phosphatase
100630816
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pyridoxal phosphatase
Mouse
Rat
Dog
pyridoxal phosphatase
Horse
pyridoxal phosphatase
Publication Statistics
PubMed Score 296.76
PubMed score by year
PubTator Score 1880.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title