Protein Summary
Required for synthesis of pyridoxal-5-phosphate from vitamin B6. The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
- ENST00000291565
- ENSP00000291565
- ENSG00000160209
- ENST00000468090
- ENSP00000418359
- C21orf124
- C21orf97
- PKH
- PNK
- PKH
- PNK
- PRED79
- C21orf97
- HEL-S-1a
- C21orf124
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.99 | ||
transcription factor perturbation | 0.99 | ||
interacting protein | 0.93 | ||
drug perturbation | 0.87 | ||
virus perturbation | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 131.52 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 315 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 131.52 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 315 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0