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Tbio
PDXDC1
Pyridoxal-dependent decarboxylase domain-containing protein 1

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396410
  • ENSP00000379691
  • ENSG00000179889
  • ENST00000450288
  • ENSP00000391147
  • ENST00000455313
  • ENSP00000406703
  • ENST00000569715
  • ENSP00000455070
  • ENST00000613798
  • ENSP00000481784
  • ENSG00000275498
  • ENST00000614573
  • ENSP00000479054
  • ENSG00000276709
  • ENST00000614833
  • ENSP00000480418
  • ENST00000618389
  • ENSP00000484595
  • ENST00000619589
  • ENSP00000478686
  • ENST00000627450
  • ENSP00000486662
  • ENST00000631842
  • ENSP00000488664

Symbol
  • KIAA0251
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
0.96
protein complex
0.94
virus perturbation
0.88
drug perturbation
0.87


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.32   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.32   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
CD70
Tbio
Novelty:  0.00420393
p_int:  0.999818703
p_ni:  0.000181297
Data Source:  BioPlex
HS1BP3
Tbio
Novelty:  0.08876712
p_int:  0.999812134
p_ni:  0.000187866
Score:  0.169
Data Source:  BioPlex,STRINGDB
CD244
Tbio
Novelty:  0.01137579
p_int:  0.999527546
p_ni:  0.000472454
Score:  0.158
Data Source:  BioPlex,STRINGDB
CMKLR1
Tchem
Family:  GPCR
Novelty:  0.00893083
p_int:  0.998974365
p_ni:  0.001025635
Data Source:  BioPlex
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
p_int:  0.993502243
p_ni:  0.006497757
Data Source:  BioPlex
HTR2C
Tclin
Family:  GPCR
Novelty:  0.00074287
p_int:  0.992252234
p_ni:  0.007747766
Data Source:  BioPlex
CHRM4
Tclin
Family:  GPCR
Novelty:  0.00759817
p_int:  0.991589567
p_ni:  0.008410433
Data Source:  BioPlex
PTGIR
Tclin
Family:  GPCR
Novelty:  0.0091906
p_int:  0.986444104
p_ni:  0.013555896
Data Source:  BioPlex
TMEM108
Tbio
Novelty:  0.08687599
p_int:  0.965404245
p_ni:  0.034595755
Data Source:  BioPlex
EDNRB
Tclin
Family:  GPCR
Novelty:  0.00053875
p_int:  0.911212515
p_ni:  0.088787485
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (56)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
4
4
5
98
omega-6 polyunsaturated fatty acid measurement
2
2
3
97.5
phosphatidylcholine measurement
18
40
171
8
97.3
triglyceride measurement
11
4
14
97.1
lysophosphatidylcholine measurement
3
2
0
8.5
93.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
5
98
omega-6 polyunsaturated fatty acid measurement
3
97.5
phosphatidylcholine measurement
171
8
97.3
triglyceride measurement
14
97.1
lysophosphatidylcholine measurement
0
8.5
93.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pyridoxal dependent decarboxylase domain containing 1
453941
Macaque
pyridoxal dependent decarboxylase domain containing 1
717685
Mouse
MGI:1920909
94184
Rat
RGD:1562597
304721
Dog
pyridoxal dependent decarboxylase domain containing 1
489996
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pyridoxal dependent decarboxylase domain containing 1
Macaque
pyridoxal dependent decarboxylase domain containing 1
Mouse
Rat
Dog
pyridoxal dependent decarboxylase domain containing 1
Publication Statistics
PubMed Score 7.32
PubMed score by year
Related Publications
No publications found