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Tbio
PDX1
Pancreas/duodenum homeobox protein 1

Protein Summary
Description
Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the earl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381033
  • ENSP00000370421
  • ENSG00000139515

Symbol
  • IPF1
  • STF1
  • GSF
  • IPF1
  • IUF1
  • IDX-1
  • MODY4
  • PDX-1
  • STF-1
  • PAGEN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
kinase
0.91
molecular function
0.91
hub protein
0.88
biological term
0.78


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 382.76   (req: < 5)
Gene RIFs: 119   (req: <= 3)
Antibodies: 753   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 382.76   (req: >= 5)
Gene RIFs: 119   (req: > 3)
Antibodies: 753   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
ONECUT1
Tbio
Family:  TF
Novelty:  0.0086548
Score:  0.989
Data Source:  STRINGDB
MAFA
Tbio
Family:  TF
Novelty:  0.0338023
Score:  0.986
Data Source:  STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.984
Data Source:  STRINGDB
IAPP
Tbio
Novelty:  0.0005195
Score:  0.973
Data Source:  STRINGDB
GCK
Tchem
Family:  Kinase
Novelty:  0.00112778
Score:  0.971
Data Source:  STRINGDB
FOXO1
Tbio
Family:  TF
Novelty:  0.00058938
Score:  0.969
Data Source:  STRINGDB
FOXA2
Tbio
Family:  TF
Novelty:  0.00244521
Score:  0.969
Data Source:  STRINGDB
NKX6-1
Tbio
Family:  TF
Novelty:  0.00776559
Score:  0.933
Data Source:  STRINGDB
FGF10
Tbio
Novelty:  0.00217451
Score:  0.93
Data Source:  STRINGDB
PAX6
Tbio
Family:  TF
Novelty:  0.00064695
Score:  0.927
Data Source:  STRINGDB
Pathways (28)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Regulation of beta-cell development
Reactome
Regulation of gene expression in beta cells
Reactome
Regulation of gene expression in early pancreatic precursor cells
Name
Explore in Pharos
Explore in Source
Developmental Biology
Regulation of beta-cell development
Regulation of gene expression in beta cells
Regulation of gene expression in early pancreatic precursor cells
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
4
4
97.3
monocyte count
2
3
3
91.9
glucose measurement
3
3
3
89.3
HbA1c measurement
1
2
2
84.2
monocyte percentage of leukocytes
1
1
1
76.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
4
97.3
monocyte count
3
91.9
glucose measurement
3
89.3
HbA1c measurement
2
84.2
monocyte percentage of leukocytes
1
76.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pancreatic and duodenal homeobox 1
VGNC:5093
452507
Mouse
MGI:102851
18609
Rat
RGD:62387
29535
Dog
pancreatic and duodenal homeobox 1
VGNC:44396
493994
Horse
pancreatic and duodenal homeobox 1
VGNC:21285
100051336
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pancreatic and duodenal homeobox 1
Mouse
Rat
Dog
pancreatic and duodenal homeobox 1
Horse
pancreatic and duodenal homeobox 1
Publication Statistics
PubMed Score 382.76
PubMed score by year
PubTator Score 483.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title