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Tbio
PDRG1
p53 and DNA damage-regulated protein 1

Protein Summary
Description
May play a role in chaperone-mediated protein folding.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000202017
  • ENSP00000202017
  • ENSG00000088356

Symbol
  • C20orf126
  • PDRG
  • PDRG
  • C20orf126
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.8
kinase perturbation
0.76
virus perturbation
0.76
cell type or tissue
0.66
tissue
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.18   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.18   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
PIH1D1
Tbio
Novelty:  0.10737369
p_int:  0.999978354
p_ni:  0.000021646
Score:  0.856
Data Source:  BioPlex,STRINGDB
UXT
Tbio
Novelty:  0.0272609
p_int:  0.999790763
p_ni:  0.000209233
p_wrong:  4e-9
Score:  0.929
Data Source:  BioPlex,STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
p_int:  0.999789002
p_ni:  0.000210998
Score:  0.653
Data Source:  BioPlex,STRINGDB
PFDN2
Tbio
Novelty:  0.08537716
p_int:  0.985251164
p_ni:  0.014748835
p_wrong:  1e-9
Score:  0.96
Data Source:  BioPlex,STRINGDB
RUVBL1
Tbio
Novelty:  0.0089115
p_int:  0.977414579
p_ni:  0.022585421
Score:  0.71
Data Source:  BioPlex,STRINGDB
RPAP3
Tbio
Family:  Enzyme
Novelty:  0.02003375
p_int:  0.958505507
p_ni:  0.041493974
p_wrong:  5.19e-7
Score:  0.795
Data Source:  BioPlex,STRINGDB
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.927780789
p_ni:  0.072211325
p_wrong:  0.000007886
Score:  0.424
Data Source:  BioPlex,STRINGDB
VBP1
Tbio
Novelty:  0.0428293
p_int:  0.911703112
p_ni:  0.08829089
p_wrong:  0.000005998
Score:  0.876
Data Source:  BioPlex,STRINGDB
PFDN4
Tbio
Novelty:  0.02133605
p_int:  0.900312758
p_ni:  0.099687161
p_wrong:  8.1e-8
Score:  0.897
Data Source:  BioPlex,STRINGDB
FBXW4
Tbio
Novelty:  0.06255177
p_int:  0.88058744
p_ni:  0.11941256
Score:  0.173
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
1
1
13.9
1
1
0
1.2
2.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
13.9
0
1.2
2.3
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
p53 and DNA damage regulated 1
VGNC:6230
100613931
Macaque
p53 and DNA damage regulated 1
712622
Mouse
MGI:1915809
68559
Rat
RGD:1305096
296278
Dog
p53 and DNA damage regulated 1
VGNC:44391
100856180
Species
Name
OMA
EggNOG
Inparanoid
Chimp
p53 and DNA damage regulated 1
Macaque
p53 and DNA damage regulated 1
Mouse
Rat
Dog
p53 and DNA damage regulated 1
Publication Statistics
PubMed Score 14.18
PubMed score by year
PubTator Score 8.92
PubTator score by year
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Related Publications
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PMID
Year
Title