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Tbio
PDPR
Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial

Protein Summary
Description
Decreases the sensitivity of PDP1 to magnesium ions, and this inhibition is reversed by the polyamine spermine. Pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate and links glycolysis to the tricarboxylic acid cycle and fatty acid synthesis. The dephosphorylation and reactivation of PDC is catalyzed by pyruvate dehydrogenase phosphatase (PDP). The dimeric PDP has a catalytic subunit and a regulatory subunit. This gene encodes the FAD-containing regulatory subunit of PDP. The encoded protein acts to decrease the sensitivity of the PDP catalytic subunit to magnesium ions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288050
  • ENSP00000288050
  • ENSG00000090857
  • ENST00000568530
  • ENSP00000457916

Symbol
  • KIAA1990
  • PDP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
kinase perturbation
0.81
small molecule perturbation
0.8
protein domain
0.73
tissue sample
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.74   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.74   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
PDP1
Tbio
Family:  Enzyme
Novelty:  0.00442352
p_int:  0.999995132
p_ni:  0.000004868
Score:  0.953
Data Source:  BioPlex,Reactome,STRINGDB
ACSM5
Tbio
Family:  Enzyme
Novelty:  0.11562771
p_int:  0.995395974
p_ni:  0.004604026
Score:  0.234
Data Source:  BioPlex,STRINGDB
TRMT1
Tbio
Family:  Enzyme
Novelty:  0.01795504
p_int:  0.989516753
p_ni:  0.010483247
Score:  0.244
Data Source:  BioPlex,STRINGDB
BPNT1
Tbio
Family:  Enzyme
Novelty:  0.1114547
p_int:  0.978257079
p_ni:  0.021742921
Score:  0.153
Data Source:  BioPlex,STRINGDB
NDUFS7
Tclin
Family:  Enzyme
Novelty:  0.01562198
p_int:  0.970685427
p_ni:  0.029314573
Score:  0.337
Data Source:  BioPlex,STRINGDB
TSC22D4
Tbio
Family:  TF
Novelty:  0.25451456
p_int:  0.968946527
p_ni:  0.031053473
Data Source:  BioPlex
TSPYL6
Tdark
Novelty:  0.68478376
p_int:  0.967668096
p_ni:  0.032331904
Data Source:  BioPlex
GATC
Tbio
Family:  Enzyme
Novelty:  0.62484697
p_int:  0.961550317
p_ni:  0.038449683
Data Source:  BioPlex
SDHB
Tchem
Family:  Enzyme
Novelty:  0.0010199
p_int:  0.939444878
p_ni:  0.060555122
Score:  0.403
Data Source:  BioPlex,STRINGDB
DKKL1
Tbio
Novelty:  0.00544618
p_int:  0.899989152
p_ni:  0.100010848
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Pyruvate metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Reactome
Regulation of pyruvate dehydrogenase (PDH) complex
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Metabolism
Pyruvate metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
Regulation of pyruvate dehydrogenase (PDH) complex
The citric acid (TCA) cycle and respiratory electron transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroimaging measurement
9
6
9
80.7
alanine measurement
2
1
1
11.6
71.6
lactate measurement
1
1
1
20.5
lymphocyte count
1
1
1
2.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroimaging measurement
9
80.7
alanine measurement
1
11.6
71.6
lactate measurement
1
20.5
lymphocyte count
1
2.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
pyruvate dehydrogenase phosphatase regulatory subunit
709861
Mouse
MGI:2442188
319518
Rat
RGD:1308307
307852
Dog
pyruvate dehydrogenase phosphatase regulatory subunit
VGNC:44390
479655
Horse
pyruvate dehydrogenase phosphatase regulatory subunit
VGNC:21279
100055025
Species
Name
OMA
EggNOG
Inparanoid
Macaque
pyruvate dehydrogenase phosphatase regulatory subunit
Mouse
Rat
Dog
pyruvate dehydrogenase phosphatase regulatory subunit
Horse
pyruvate dehydrogenase phosphatase regulatory subunit
Publication Statistics
PubMed Score 37.74
PubMed score by year
PubTator Score 9.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title