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Tchem
PDPK1
3-phosphoinositide-dependent protein kinase 1

Protein Summary
Description
Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage. Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268673
  • ENSP00000268673
  • ENSG00000140992
  • ENST00000342085
  • ENSP00000344220
  • ENST00000441549
  • ENSP00000395357

Symbol
  • PDK1
  • PDK1
  • PDPK2
  • PDPK2P
  • PRO0461
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
hub protein
0.99
pathway
0.99
kinase
0.97


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.38   (req: < 5)
Gene RIFs: 115   (req: <= 3)
Antibodies: 876   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.38   (req: >= 5)
Gene RIFs: 115   (req: > 3)
Antibodies: 876   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 284
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (180)
WDR5
Tchem
Novelty:  0.0059945
p_int:  0.999999736
p_ni:  2.64e-7
Score:  0.355
Data Source:  BioPlex,STRINGDB
SDC2
Tbio
Novelty:  0.00597758
p_int:  0.999997992
p_ni:  0.000002008
Data Source:  BioPlex
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.99987861
p_ni:  0.00012139
Score:  0.183
Data Source:  BioPlex,STRINGDB
SERPINA4
Tbio
Novelty:  0.00483207
p_int:  0.996941603
p_ni:  0.003058396
p_wrong:  1e-9
Score:  0.31
Data Source:  BioPlex,STRINGDB
FAM199X
Tdark
Novelty:  1.32503264
p_int:  0.98340554
p_ni:  0.00565862
p_wrong:  0.01093584
Score:  0.864
Data Source:  BioPlex,STRINGDB
SCRN2
Tdark
Family:  Enzyme
Novelty:  1.63547022
p_int:  0.951900578
p_ni:  0.0480831
p_wrong:  0.000016322
Score:  0.188
Data Source:  BioPlex,STRINGDB
CPA4
Tchem
Family:  Enzyme
Novelty:  0.01439845
p_int:  0.850785284
p_ni:  0.149214715
p_wrong:  1e-9
Score:  0.222
Data Source:  BioPlex,STRINGDB
TBL2
Tbio
Novelty:  0.04754985
p_int:  0.836131987
p_ni:  0.163868013
Score:  0.533
Data Source:  BioPlex,STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.999
Data Source:  Reactome,STRINGDB
AKT2
Tchem
Family:  Kinase
Novelty:  0.00167027
Score:  0.999
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (7)
Explore Nearest Tclin Targets
1 – 2 of 2
PIK3CA
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  21
more:  17 more common pathways
PIK3CD
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  21
more:  17 more common pathways
Pathways (157)
Activation of AKT2 (R-HSA-165158)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 68
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of AKT2
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Adaptive Immune System
Reactome
C-type lectin receptors (CLRs)
Reactome
CD28 co-stimulation
Name
Explore in Pharos
Explore in Source
Activation of AKT2
Activation of NMDA receptors and postsynaptic events
Adaptive Immune System
C-type lectin receptors (CLRs)
CD28 co-stimulation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (54)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
1
1
0
8.7
70.2
mean reticulocyte volume
1
1
1
35
BMI-adjusted hip circumference
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
0
8.7
70.2
mean reticulocyte volume
1
35
BMI-adjusted hip circumference
1
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
3-phosphoinositide dependent protein kinase 1
VGNC:13762
467875
Mouse
MGI:1338068
18607
Rat
RGD:620307
81745
Dog
3-phosphoinositide dependent protein kinase 1
VGNC:54055
479875
Horse
3-phosphoinositide dependent protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:8816]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
3-phosphoinositide dependent protein kinase 1
Mouse
Rat
Dog
3-phosphoinositide dependent protein kinase 1
Horse
3-phosphoinositide dependent protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:8816]
Publication Statistics
PubMed Score 233.38
PubMed score by year
PubTator Score 104.05
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title