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Tbio
PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

Protein Summary
Description
Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. This gene is a mitochondrial protein that functions as a phosphatase and is involved in the enzymatic resetting of the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311765
  • ENSP00000309548
  • ENSG00000172840

Symbol
  • KIAA1348
  • PPM2B
  • PDPC 2
  • PPM2C2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.68
tissue sample
0.66
histone modification site profile
0.64
microRNA
0.64
transcription factor
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.62   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.62   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
NPB
Tdark
Novelty:  0.00936692
p_int:  0.999998033
p_ni:  0.000001967
Score:  0.171
Data Source:  BioPlex,STRINGDB
TMEM184A
Tbio
Novelty:  0.16408207
p_int:  0.999997382
p_ni:  0.000002616
p_wrong:  2e-9
Score:  0.192
Data Source:  BioPlex,STRINGDB
NDUFS7
Tclin
Family:  Enzyme
Novelty:  0.01562198
p_int:  0.999817919
p_ni:  0.000166344
p_wrong:  0.000015737
Data Source:  BioPlex
NOX5
Tchem
Family:  Enzyme
Novelty:  0.00743692
p_int:  0.991203791
p_ni:  0.000555628
p_wrong:  0.008240581
Score:  0.245
Data Source:  BioPlex,STRINGDB
SPINK2
Tdark
Family:  Enzyme
Novelty:  0.06832697
p_int:  0.990132129
p_ni:  0.000877819
p_wrong:  0.008990052
Score:  0.165
Data Source:  BioPlex,STRINGDB
ACP7
Tdark
Family:  Enzyme
Novelty:  0.05718825
p_int:  0.960708406
p_ni:  0.000058557
p_wrong:  0.039233036
Score:  0.425
Data Source:  BioPlex,STRINGDB
PDPR
Tbio
Family:  Enzyme
Novelty:  0.04223174
Score:  0.983
Data Source:  Reactome,STRINGDB
DLD
Tbio
Family:  Enzyme
Novelty:  0.00214298
Score:  0.972
Data Source:  STRINGDB
PDHA1
Tbio
Family:  Enzyme
Novelty:  0.00392231
Score:  0.972
Data Source:  STRINGDB
DLAT
Tbio
Family:  Enzyme
Novelty:  0.00311191
Score:  0.964
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Pyruvate metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Reactome
Regulation of pyruvate dehydrogenase (PDH) complex
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Metabolism
Pyruvate metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
Regulation of pyruvate dehydrogenase (PDH) complex
The citric acid (TCA) cycle and respiratory electron transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
82.2
blood protein measurement
2
2
2
81.5
diastolic blood pressure
1
1
1
80.3
apolipoprotein A 1 measurement
3
5
5
79.8
high density lipoprotein cholesterol measurement
21
4
23
77.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
82.2
blood protein measurement
2
81.5
diastolic blood pressure
1
80.3
apolipoprotein A 1 measurement
5
79.8
high density lipoprotein cholesterol measurement
23
77.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
pyruvate dehyrogenase phosphatase catalytic subunit 2
694851
Mouse
MGI:1918878
382051
Rat
RGD:628812
246311
Dog
pyruvate dehyrogenase phosphatase catalytic subunit 2
VGNC:44389
489771
Horse
pyruvate dehyrogenase phosphatase catalytic subunit 2
VGNC:21278
100065629
Species
Name
OMA
EggNOG
Inparanoid
Macaque
pyruvate dehyrogenase phosphatase catalytic subunit 2
Mouse
Rat
Dog
pyruvate dehyrogenase phosphatase catalytic subunit 2
Horse
pyruvate dehyrogenase phosphatase catalytic subunit 2
Publication Statistics
PubMed Score 44.62
PubMed score by year
PubTator Score 20.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title