Tbio PDP1 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

Protein Summary

Description

Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]

Uniprot Accession IDs

• Q9P0J1
• B3KX71
• J3KPU0
• Q5U5K1
• PDP 1

Gene Name

• PDP1

Ensembl ID

• ENST00000297598
• ENSP00000297598
• ENSG00000164951
• ENST00000396200
• ENSP00000379503
• ENST00000517764
• ENSP00000430380
• ENST00000520728
• ENSP00000428317

Symbol

• PDP
• PPM2C
• PDH
• PDP
• PDPC
• PPM2A
• PPM2C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.88
histone modification site profile	0.86
transcription factor perturbation	0.8
transcription factor	0.72
tissue sample	0.69

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Protein Phosphatase / [Pyruvate Dehydrogenase [Acetyl-transferring]]-phosphatase 1, Mitochondrial

Protein / Enzyme Modulator / Kinase Modulator / Kinase Inhibitor / [Pyruvate Dehydrogenase [Acetyl-transferring]]-phosphatase 1, Mitochondrial

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Protein Phosphatase / [Pyruvate Dehydrogenase [Acetyl-transferring]]-phosphatase 1, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 251.21   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 249   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 251.21   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 249   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0