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Tbio
PDLIM7
PDZ and LIM domain protein 7

Protein Summary
Description
May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355572
  • ENSP00000347776
  • ENSG00000196923
  • ENST00000355841
  • ENSP00000348099
  • ENST00000359895
  • ENSP00000352964
  • ENST00000393551
  • ENSP00000377182
  • ENST00000486828
  • ENSP00000439157
  • ENST00000493815
  • ENSP00000431236

Symbol
  • ENIGMA
  • LMP1
  • LMP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
disease perturbation
0.96
interacting protein
0.96
disease
0.93
PubMedID
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.62   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.62   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (142)
PTPN14
Tbio
Family:  Enzyme
Novelty:  0.01333024
p_int:  0.99992544
p_ni:  0.00007456
Score:  0.246
Data Source:  BioPlex,STRINGDB
PDLIM5
Tbio
Novelty:  0.0040646
p_int:  0.999905674
p_ni:  0.000094326
Score:  0.55
Data Source:  BioPlex,STRINGDB
ZBTB10
Tbio
Family:  TF
Novelty:  0.05707286
p_int:  0.999835631
p_ni:  0.000164369
Score:  0.533
Data Source:  BioPlex,STRINGDB
LPXN
Tbio
Novelty:  0.00796678
p_int:  0.999711401
p_ni:  0.000284417
p_wrong:  0.000004181
Score:  0.528
Data Source:  BioPlex,STRINGDB
SLFN12
Tbio
Novelty:  0.11423977
p_int:  0.999360398
p_wrong:  0.000639602
Score:  0.282
Data Source:  BioPlex,STRINGDB
LPP
Tbio
Novelty:  0.00624048
p_int:  0.994651556
p_ni:  0.0028002
p_wrong:  0.002548244
Score:  0.574
Data Source:  BioPlex,STRINGDB
PRICKLE3
Tbio
Novelty:  0.26347141
p_int:  0.993009987
p_ni:  0.006990013
p_wrong:  1e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
BAG3
Tbio
Novelty:  0.0042967
p_int:  0.991687081
p_ni:  0.008312919
Score:  0.178
Data Source:  BioPlex,STRINGDB
ZCCHC7
Tbio
Novelty:  0.01655453
p_int:  0.990725156
p_ni:  0.009274844
Score:  0.163
Data Source:  BioPlex,STRINGDB
ZNF576
Tdark
Family:  TF
Novelty:  13.18548387
p_int:  0.989268555
p_ni:  0.010731443
p_wrong:  2e-9
Score:  0.645
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (53)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
RET signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
RET signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
8
6
9
15.2
99.1
partial thromboplastin time
2
2
2
96.1
creatinine measurement
5
5
6
91.5
self reported educational attainment
2
2
2
79.4
blood metabolite measurement
2
1
2
77.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
9
15.2
99.1
partial thromboplastin time
2
96.1
creatinine measurement
6
91.5
self reported educational attainment
2
79.4
blood metabolite measurement
2
77.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PDZ and LIM domain 7
VGNC:4127
462308
Macaque
PDZ and LIM domain 7
706581
Mouse
MGI:1914649
67399
Rat
RGD:628769
286908
Horse
PDZ and LIM domain 7
VGNC:21277
100058356
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PDZ and LIM domain 7
Macaque
PDZ and LIM domain 7
Mouse
Rat
Horse
PDZ and LIM domain 7
Publication Statistics
PubMed Score 192.62
PubMed score by year
PubTator Score 1177.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title