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Tbio
PDLIM3
PDZ and LIM domain protein 3

Protein Summary
Description
May play a role in the organization of actin filament arrays within muscle cells. The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this gene may play a role in myotonic dystrophy. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284767
  • ENSP00000284767
  • ENSG00000154553
  • ENST00000284771
  • ENSP00000284771

Symbol
  • ALP
  • ALP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.89
transcription factor perturbation
0.74
small molecule perturbation
0.72
histone modification site profile
0.68
tissue sample
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.92   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.92   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
NEB
Tbio
Novelty:  0.00174728
Score:  0.877
Data Source:  STRINGDB
TNNC2
Tbio
Novelty:  0.07759506
Score:  0.875
Data Source:  STRINGDB
PDLIM7
Tbio
Novelty:  0.00544518
Score:  0.873
Data Source:  STRINGDB
MYL1
Tbio
Novelty:  0.00360262
Score:  0.866
Data Source:  STRINGDB
CAV3
Tbio
Novelty:  0.00190092
Score:  0.852
Data Source:  STRINGDB
MYBPC3
Tbio
Novelty:  0.00297478
Score:  0.81
Data Source:  STRINGDB
ACTN2
Tbio
Novelty:  0.00615882
Score:  0.789
Data Source:  STRINGDB
SRL
Tdark
Novelty:  0.03172682
Score:  0.705
Data Source:  STRINGDB
LDB3
Tbio
Novelty:  0.01178009
Score:  0.685
Data Source:  STRINGDB
SORBS1
Tbio
Novelty:  0.01480301
Score:  0.676
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
3
3
74
self reported educational attainment
1
1
1
40.8
body height
1
1
1
30.2
IGF-1 measurement
1
1
1
22.8
serum gamma-glutamyl transferase measurement
1
1
1
12.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
3
74
self reported educational attainment
1
40.8
body height
1
30.2
IGF-1 measurement
1
22.8
serum gamma-glutamyl transferase measurement
1
12.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PDZ and LIM domain 3
VGNC:13091
461639
Macaque
PDZ and LIM domain 3
695779
Mouse
MGI:1859274
53318
Rat
RGD:620427
114108
Dog
PDZ and LIM domain 3
VGNC:44385
482907
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PDZ and LIM domain 3
Macaque
PDZ and LIM domain 3
Mouse
Rat
Dog
PDZ and LIM domain 3
Publication Statistics
PubMed Score 22.92
PubMed score by year
PubTator Score 21.30
PubTator score by year
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Related Publications
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PMID
Year
Title