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Tbio
PDLIM1
PDZ and LIM domain protein 1

Protein Summary
Description
Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity). This gene encodes a member of the enigma protein family. The protein contains two protein interacting domains, a PDZ domain at the amino terminal end and one to three LIM domains at the carboxyl terminal. It is a cytoplasmic protein associated with the cytoskeleton. The protein may function as an adapter to bring other LIM-interacting proteins to the cytoskeleton. Pseudogenes associated with this gene are located on chromosomes 3, 14 and 17. [provided by RefSeq, Oct 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329399
  • ENSP00000360305
  • ENSG00000107438

Symbol
  • CLIM1
  • CLP36
  • CLIM1
  • CLP36
  • CLP-36
  • hCLIM1
  • HEL-S-112
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
transcription factor perturbation
0.99
PubMedID
0.94
transcription factor binding site profile
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.45   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 361   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.45   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 361   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
ACTN3
Tbio
Novelty:  0.00375035
p_int:  1
Score:  0.596
Data Source:  BioPlex,STRINGDB
NUDT12
Tbio
Family:  Enzyme
Novelty:  0.18740719
p_int:  0.999930627
p_ni:  0.000069369
p_wrong:  4e-9
Score:  0.239
Data Source:  BioPlex,STRINGDB
ACTN1
Tbio
Novelty:  0.00654004
p_int:  0.996270775
p_ni:  0.003729225
Score:  0.861
Data Source:  BioPlex,STRINGDB
ACTN2
Tbio
Novelty:  0.00615882
p_int:  0.963818161
p_ni:  0.036181839
Score:  0.806
Data Source:  BioPlex,STRINGDB
ACTN4
Tbio
Novelty:  0.0040236
p_int:  0.92728941
p_ni:  0.07271059
Score:  0.764
Data Source:  BioPlex,STRINGDB
SOX2
Tbio
Family:  TF
Novelty:  0.00037089
p_int:  0.893544023
p_ni:  0.106455968
p_wrong:  1e-8
Score:  0.206
Data Source:  BioPlex,STRINGDB
STK35
Tchem
Family:  Kinase
Novelty:  0.19556072
Score:  0.975
Data Source:  STRINGDB
STMN1
Tbio
Novelty:  0.00117369
Score:  0.868
Data Source:  STRINGDB
ACSL5
Tchem
Family:  Enzyme
Novelty:  0.00850919
Score:  0.651
Data Source:  STRINGDB
PALLD
Tbio
Novelty:  0.01191944
Score:  0.594
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
5
91.9
leukocyte count
1
1
1
56.6
hemoglobin measurement
2
1
2
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
5
91.9
leukocyte count
1
56.6
hemoglobin measurement
2
47.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PDZ and LIM domain 1
VGNC:7247
450627
Macaque
PDZ and LIM domain 1
702998
Mouse
MGI:1860611
54132
Rat
RGD:68324
54133
Dog
PDZ and LIM domain 1
VGNC:53007
477779
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PDZ and LIM domain 1
Macaque
PDZ and LIM domain 1
Mouse
Rat
Dog
PDZ and LIM domain 1
Publication Statistics
PubMed Score 38.45
PubMed score by year
PubTator Score 23.84
PubTator score by year
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Related Publications
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PMID
Year
Title