You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
PDK4
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial

Protein Summary
Description
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000005178
  • ENSP00000005178
  • ENSG00000004799

Symbol
  • PDHK4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.92
PubMedID
0.91
molecular function
0.9
small molecule perturbation
0.8
biological process
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 266.4   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 586   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 266.4   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 586   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (133)
PDK2
Tchem
Family:  Kinase
Novelty:  0.01502257
p_int:  0.999999839
p_ni:  1.61e-7
Score:  0.85
Data Source:  BioPlex,STRINGDB
PDK3
Tchem
Family:  Kinase
Novelty:  0.05009442
p_int:  0.999934625
p_ni:  0.000065375
Score:  0.831
Data Source:  BioPlex,STRINGDB
PDK1
Tchem
Family:  Kinase
Novelty:  0.0078496
p_int:  0.999664796
p_ni:  0.000335204
Score:  0.828
Data Source:  BioPlex,STRINGDB
NARS2
Tbio
Family:  Enzyme
Novelty:  0.01879317
p_int:  0.997701737
p_ni:  0.002298262
p_wrong:  1e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
PDHA1
Tbio
Family:  Enzyme
Novelty:  0.00392231
Score:  0.976
Data Source:  Reactome,STRINGDB
DLAT
Tbio
Family:  Enzyme
Novelty:  0.00311191
Score:  0.956
Data Source:  Reactome,STRINGDB
PDHX
Tbio
Family:  Enzyme
Novelty:  0.00946631
Score:  0.947
Data Source:  Reactome,STRINGDB
PDHB
Tbio
Family:  Enzyme
Novelty:  0.01018086
Score:  0.946
Data Source:  Reactome,STRINGDB
PDHA2
Tbio
Family:  Enzyme
Novelty:  0.06188763
Score:  0.945
Data Source:  Reactome,STRINGDB
DLD
Tbio
Family:  Enzyme
Novelty:  0.00214298
Score:  0.936
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (30)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Pyruvate metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Reactome
Regulation of pyruvate dehydrogenase (PDH) complex
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Metabolism
Pyruvate metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
Regulation of pyruvate dehydrogenase (PDH) complex
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
1
2
49.5
self reported educational attainment
1
1
1
33.1
body mass index
2
1
2
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
49.5
self reported educational attainment
1
33.1
body mass index
2
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pyruvate dehydrogenase kinase 4
VGNC:14062
472448
Macaque
pyruvate dehydrogenase kinase 4
698726
Mouse
MGI:1351481
27273
Rat
RGD:69061
89813
Dog
pyruvate dehydrogenase kinase 4
VGNC:44383
482310
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pyruvate dehydrogenase kinase 4
Macaque
pyruvate dehydrogenase kinase 4
Mouse
Rat
Dog
pyruvate dehydrogenase kinase 4
Publication Statistics
PubMed Score 266.40
PubMed score by year
PubTator Score 120.58
PubTator score by year
Patents
Patents by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title