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Tchem
PDK2
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial

Protein Summary
Description
Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis. This gene en ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000007708
  • ENSP00000007708
  • ENSG00000005882
  • ENST00000503176
  • ENSP00000420927
  • ENST00000614357
  • ENSP00000481915

Symbol
  • PDHK2
  • PDHK2
  • PDKII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
virus perturbation
0.72
kinase perturbation
0.71
biological process
0.69
tissue
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.73   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 496   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.73   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 496   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 86
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (86)
VER-246608
Rendered image for VER-246608
CHEMBL4591977
Rendered image for CHEMBL4591977
AZD7545
Rendered image for AZD7545
US9040717, Compound (3)
Rendered image for US9040717, Compound (3)
CHEMBL3673096
Rendered image for CHEMBL3673096
CHEMBL4575355
Rendered image for CHEMBL4575355
CHEMBL4551410
Rendered image for CHEMBL4551410
US9040717, Compound (A)
Rendered image for US9040717, Compound (A)
US9040717, Compound (D)
Rendered image for US9040717, Compound (D)
US9040717, Compound (C)
Rendered image for US9040717, Compound (C)
Protein-Protein Interactions (83)
PDK1
Tchem
Family:  Kinase
Novelty:  0.0078496
p_int:  0.999999962
p_ni:  3.8e-8
Score:  0.91
Data Source:  BioPlex,STRINGDB
FOXD4
Tbio
Family:  TF
Novelty:  0.11166611
p_int:  0.999999922
p_ni:  7.8e-8
Score:  0.782
Data Source:  BioPlex,STRINGDB
PDK3
Tchem
Family:  Kinase
Novelty:  0.05009442
p_int:  0.999999849
p_ni:  1.51e-7
Score:  0.869
Data Source:  BioPlex,STRINGDB
PDK4
Tchem
Family:  Kinase
Novelty:  0.00410067
p_int:  0.999999839
p_ni:  1.61e-7
Score:  0.85
Data Source:  BioPlex,STRINGDB
SYT12
Tbio
Novelty:  0.03410873
p_int:  0.999999044
p_ni:  9.55e-7
Score:  0.657
Data Source:  BioPlex,STRINGDB
STAT5A
Tchem
Family:  TF
Novelty:  0.00074026
p_int:  0.998097989
p_ni:  0.001902007
p_wrong:  3e-9
Score:  0.841
Data Source:  BioPlex,STRINGDB
ACAD9
Tbio
Family:  Enzyme
Novelty:  0.03238308
p_int:  0.975599459
p_ni:  0.006553868
p_wrong:  0.017846672
Score:  0.545
Data Source:  BioPlex,STRINGDB
PDHB
Tbio
Family:  Enzyme
Novelty:  0.01018086
p_int:  0.974433226
p_ni:  0.007660646
p_wrong:  0.017906127
Score:  0.991
Data Source:  BioPlex,Reactome,STRINGDB
FECH
Tchem
Family:  Enzyme
Novelty:  0.00282289
p_int:  0.971331678
p_ni:  0.028668309
p_wrong:  1.3e-8
Score:  0.262
Data Source:  BioPlex,STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.988
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Pyruvate metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Reactome
Regulation of pyruvate dehydrogenase (PDH) complex
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Metabolism
Pyruvate metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
Regulation of pyruvate dehydrogenase (PDH) complex
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
5
5
92.2
cup-to-disc ratio measurement
2
2
2
57.2
1
1
1
31.4
mathematical ability
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
5
92.2
cup-to-disc ratio measurement
2
57.2
1
31.4
mathematical ability
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pyruvate dehydrogenase kinase 2
VGNC:9505
468402
Macaque
pyruvate dehydrogenase kinase 2
704169
Mouse
MGI:1343087
18604
Rat
RGD:69428
81530
Dog
pyruvate dehydrogenase kinase 2
VGNC:44381
491075
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pyruvate dehydrogenase kinase 2
Macaque
pyruvate dehydrogenase kinase 2
Mouse
Rat
Dog
pyruvate dehydrogenase kinase 2
Publication Statistics
PubMed Score 60.73
PubMed score by year
PubTator Score 66.63
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title