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Tdark
PDIK1L
Serine/threonine-protein kinase PDIK1L

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374269
  • ENSP00000363387
  • ENSG00000175087
  • ENST00000374271
  • ENSP00000363389
  • ENST00000619836
  • ENSP00000480635

Symbol
  • CLIK1L
  • CLIK1L
  • STK35L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
transcription factor binding site profile
0.85
microRNA
0.81
transcription factor
0.69
histone modification site profile
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.55   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.55   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
CTDSPL2
Tbio
Family:  Enzyme
Novelty:  0.23254058
p_int:  0.999999999
Score:  0.554
Data Source:  BioPlex,STRINGDB
C1orf174
Tdark
Novelty:  4.20172485
p_int:  0.999998069
p_ni:  0.000001757
p_wrong:  1.75e-7
Score:  0.403
Data Source:  BioPlex,STRINGDB
HSP90AB4P
Tdark
p_int:  0.999978488
p_ni:  0.000021512
Data Source:  BioPlex
HSP90AA5P
Tdark
p_int:  0.999956693
p_ni:  0.000043306
Data Source:  BioPlex
FKBP5
Tchem
Family:  Enzyme
Novelty:  0.00214511
p_int:  0.988829243
p_ni:  0.011170757
Data Source:  BioPlex
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
p_int:  0.975873309
p_ni:  0.009751536
p_wrong:  0.014375155
Score:  0.393
Data Source:  BioPlex,STRINGDB
CDC37
Tbio
Novelty:  0.03730196
p_int:  0.970513978
p_ni:  0.029486022
Score:  0.161
Data Source:  BioPlex,STRINGDB
HSP90AA1
Tchem
Novelty:  0.00016774
p_int:  0.847909993
p_ni:  0.152090007
Score:  0.208
Data Source:  BioPlex,STRINGDB
HSP90AB1
Tchem
Novelty:  0.00907961
p_int:  0.785104748
p_ni:  0.214895252
Score:  0.207
Data Source:  BioPlex,STRINGDB
TAF1B
Tbio
Family:  Enzyme
Novelty:  0.10174314
Score:  0.731
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
65.5
electrocardiography
1
1
9
62.1
BMI-adjusted waist-hip ratio
1
1
1
35
waist-hip ratio
1
1
1
30.2
IGF-1 measurement
1
1
1
27.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
65.5
electrocardiography
9
62.1
BMI-adjusted waist-hip ratio
1
35
waist-hip ratio
1
30.2
IGF-1 measurement
1
27.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PDLIM1 interacting kinase 1 like
VGNC:1441
736983
Macaque
PDLIM1 interacting kinase 1 like
719774
Mouse
MGI:2385213
230809
Rat
RGD:1307476
313609
Dog
PDLIM1 interacting kinase 1 like
VGNC:44379
100684736
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PDLIM1 interacting kinase 1 like
Macaque
PDLIM1 interacting kinase 1 like
Mouse
Rat
Dog
PDLIM1 interacting kinase 1 like
Publication Statistics
PubMed Score 2.55
PubMed score by year
PubTator Score 50.56
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title