Tchem PDIA6 Protein disulfide-isomerase A6

Protein Summary

Description

May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936). This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

Uniprot Accession IDs

• Q15084
• B3KY95
• B5MCQ5
• B7Z254
• B7Z4M8
• F8WA83
• Q53RC7
• Q6ZSH5
• Q99778

Gene Name

• PDIA6

Ensembl ID

• ENST00000272227
• ENSP00000272227
• ENSG00000143870
• ENST00000381611
• ENSP00000371024
• ENST00000404371
• ENSP00000385385
• ENST00000404824
• ENSP00000384459
• ENST00000540494
• ENSP00000438778
• ENST00000617249
• ENSP00000481892

Symbol

• ERP5
• P5
• TXNDC7
• P5
• ERP5
• TXNDC7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
kinase perturbation	1
transcription factor perturbation	0.97
drug perturbation	0.96
hub protein	0.95

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.63   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 217   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.63   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0