You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
PDIA6
Protein disulfide-isomerase A6

Protein Summary
Description
May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936). This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoform ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272227
  • ENSP00000272227
  • ENSG00000143870
  • ENST00000381611
  • ENSP00000371024
  • ENST00000404371
  • ENSP00000385385
  • ENST00000404824
  • ENSP00000384459
  • ENST00000540494
  • ENSP00000438778
  • ENST00000617249
  • ENSP00000481892

Symbol
  • ERP5
  • P5
  • TXNDC7
  • P5
  • ERP5
  • TXNDC7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
1
transcription factor perturbation
0.97
drug perturbation
0.96
hub protein
0.95


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.5   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 217   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.5   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (224)
VWA1
Tbio
Novelty:  0.00212445
p_int:  0.999958994
p_ni:  0.000041005
p_wrong:  2e-9
Score:  0.92
Data Source:  BioPlex,STRINGDB
JMJD8
Tbio
Novelty:  0.31175159
p_int:  0.995306145
p_ni:  0.00368769
p_wrong:  0.001006165
Score:  0.201
Data Source:  BioPlex,STRINGDB
HNRNPLL
Tbio
Novelty:  0.0498467
p_int:  0.988354237
p_ni:  0.011645763
Score:  0.196
Data Source:  BioPlex,STRINGDB
BTBD9
Tbio
Novelty:  0.02793632
p_int:  0.980182618
p_ni:  0.019817382
Score:  0.199
Data Source:  BioPlex,STRINGDB
TXNRD1
Tclin
Family:  Enzyme
Novelty:  0.00299018
p_int:  0.976309544
p_ni:  0.023690456
Score:  0.788
Data Source:  BioPlex,STRINGDB
ISCA1
Tbio
Novelty:  0.01288069
p_int:  0.961145986
p_ni:  0.038589105
p_wrong:  0.000264909
Score:  0.2
Data Source:  BioPlex,STRINGDB
KLHL24
Tbio
Novelty:  0.04032749
p_int:  0.918268295
p_ni:  0.081729087
p_wrong:  0.000002618
Score:  0.24
Data Source:  BioPlex,STRINGDB
PLS1
Tbio
Novelty:  0.00538817
p_int:  0.910641355
p_ni:  0.089355577
p_wrong:  0.000003068
Score:  0.183
Data Source:  BioPlex,STRINGDB
ZHX3
Tbio
Family:  TF
Novelty:  0.13068792
p_int:  0.759096115
p_ni:  0.240696156
p_wrong:  0.000207729
Score:  0.519
Data Source:  BioPlex,STRINGDB
DNAJC3
Tbio
Novelty:  0.02129782
Score:  0.997
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
IRE1alpha activates chaperones (R-HSA-381070)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
IRE1alpha activates chaperones
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
IRE1alpha activates chaperones
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
2
4
1
88.6
mathematical ability
4
3
4
88.6
cognitive function measurement
1
1
1
64.4
1
1
1
21.5
intelligence
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
1
88.6
mathematical ability
4
88.6
cognitive function measurement
1
64.4
1
21.5
intelligence
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein disulfide isomerase family A member 6
VGNC:2927
459509
Macaque
protein disulfide isomerase family A member 6
706781
Mouse
MGI:1919103
71853
Rat
RGD:628688
286906
Dog
protein disulfide isomerase family A member 6
475668
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein disulfide isomerase family A member 6
Macaque
protein disulfide isomerase family A member 6
Mouse
Rat
Dog
protein disulfide isomerase family A member 6
Publication Statistics
PubMed Score 60.50
PubMed score by year
PubTator Score 43.12
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title