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Tbio
PDIA5
Protein disulfide-isomerase A5

Protein Summary
Description
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. The N-terminal TRX-like domain is the primary binding site for the major ER chaperone calreticulin and possibly other proteins and substrates as well. Alternative splicing results in multiple protein- and non-protein-coding transcript variants. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316218
  • ENSP00000323313
  • ENSG00000065485
  • ENST00000489923
  • ENSP00000417520

Symbol
  • PDIR
  • PDIR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.9
disease perturbation
0.87
transcription factor binding site profile
0.74
cellular component
0.66
kinase perturbation
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.48   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 172   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.48   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
BIRC2
Tchem
Novelty:  0.00199701
p_int:  0.999996205
p_ni:  0.000003795
Data Source:  BioPlex
WFDC2
Tbio
Novelty:  0.0136923
p_int:  0.999960428
p_ni:  0.000039572
Score:  0.167
Data Source:  BioPlex,STRINGDB
CNPY2
Tbio
Novelty:  0.090889
p_int:  0.99979902
p_ni:  0.00020098
Score:  0.216
Data Source:  BioPlex,STRINGDB
PATE1
Tbio
Novelty:  0.0705075
p_int:  0.999756479
p_ni:  0.000243521
Data Source:  BioPlex
ANTXR1
Tbio
Novelty:  0.00508081
p_int:  0.999171098
p_ni:  0.000828902
Data Source:  BioPlex
MUCL1
Tbio
Novelty:  0.05915667
p_int:  0.998385794
p_ni:  0.001614206
Data Source:  BioPlex
NENF
Tbio
Novelty:  0.02262843
p_int:  0.997802274
p_ni:  0.002197726
Score:  0.555
Data Source:  BioPlex,STRINGDB
CCL22
Tbio
Novelty:  0.00245992
p_int:  0.994868374
p_ni:  0.005131626
Data Source:  BioPlex
TRAF2
Tbio
Novelty:  0.00983658
p_int:  0.989849659
p_ni:  0.010150302
p_wrong:  3.9e-8
Data Source:  BioPlex
MYDGF
Tbio
Novelty:  0.01523668
p_int:  0.989594082
p_ni:  0.010405918
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
IRE1alpha activates chaperones (R-HSA-381070)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
IRE1alpha activates chaperones
Reactome
Metabolism of proteins
Reactome
Unfolded Protein Response (UPR)
Reactome
XBP1(S) activates chaperone genes
Name
Explore in Pharos
Explore in Source
IRE1alpha activates chaperones
Metabolism of proteins
Unfolded Protein Response (UPR)
XBP1(S) activates chaperone genes
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
3
3
2
2.2
96
mean platelet volume
2
2
2
94.3
platelet crit
2
1
2
64.4
glucose measurement
1
1
1
54.4
HbA1c measurement
1
1
1
52.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2.2
96
mean platelet volume
2
94.3
platelet crit
2
64.4
glucose measurement
1
54.4
HbA1c measurement
1
52.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein disulfide isomerase family A member 5
VGNC:2504
745680
Macaque
protein disulfide isomerase family A member 5
715226
Mouse
MGI:1919849
72599
Rat
RGD:1359236
360722
Dog
protein disulfide isomerase family A member 5
VGNC:44378
478589
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein disulfide isomerase family A member 5
Macaque
protein disulfide isomerase family A member 5
Mouse
Rat
Dog
protein disulfide isomerase family A member 5
Publication Statistics
PubMed Score 16.48
PubMed score by year
PubTator Score 6.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title