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Tbio
PDHA1
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

Protein Summary
Description
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms h ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379806
  • ENSP00000369134
  • ENSG00000131828
  • ENST00000422285
  • ENSP00000394382
  • ENST00000540249
  • ENSP00000440761
  • ENST00000545074
  • ENSP00000438550

Symbol
  • PHE1A
  • PDHA
  • PDHAD
  • PHE1A
  • PDHCE1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
transcription factor perturbation
0.94
histone modification site profile
0.88
interacting protein
0.86


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 267.94   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 601   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 267.94   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 601   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (185)
PDHB
Tbio
Family:  Enzyme
Novelty:  0.01018086
p_int:  0.999873864
p_ni:  0.000126136
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PDK3
Tchem
Family:  Kinase
Novelty:  0.05009442
p_int:  0.999277737
p_ni:  0.000722263
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
STAT5A
Tchem
Family:  TF
Novelty:  0.00074026
p_int:  0.987428381
p_ni:  0.012571619
Score:  0.843
Data Source:  BioPlex,STRINGDB
DLD
Tbio
Family:  Enzyme
Novelty:  0.00214298
p_int:  0.973696183
p_ni:  0.026303817
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
MIF
Tchem
Novelty:  0.00056843
p_int:  0.952296575
p_ni:  0.047703425
Data Source:  BioPlex
FOXD4
Tbio
Family:  TF
Novelty:  0.11166611
p_int:  0.897442173
p_ni:  0.102557827
Score:  0.72
Data Source:  BioPlex,STRINGDB
DLAT
Tbio
Family:  Enzyme
Novelty:  0.00311191
Score:  0.999
Data Source:  Reactome,STRINGDB
PDHX
Tbio
Family:  Enzyme
Novelty:  0.00946631
Score:  0.998
Data Source:  Reactome,STRINGDB
OGDH
Tbio
Family:  Enzyme
Novelty:  0.00674601
Score:  0.994
Data Source:  STRINGDB
BCKDHB
Tbio
Family:  Enzyme
Novelty:  0.02234969
Score:  0.993
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (142)
Glyoxylate metabolism and glycine degradation (R-HSA-389661)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glyoxylate metabolism and glycine degradation
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Pyruvate metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Name
Explore in Pharos
Explore in Source
Glyoxylate metabolism and glycine degradation
Metabolism
Metabolism of amino acids and derivatives
Pyruvate metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pyruvate dehydrogenase E1 alpha 1 subunit
VGNC:14835
465525
Macaque
pyruvate dehydrogenase E1 alpha 1 subunit
100423990
Mouse
MGI:97532
18597
Rat
RGD:3286
29554
Dog
pyruvate dehydrogenase E1 alpha 1 subunit
VGNC:54179
480858
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pyruvate dehydrogenase E1 alpha 1 subunit
Macaque
pyruvate dehydrogenase E1 alpha 1 subunit
Mouse
Rat
Dog
pyruvate dehydrogenase E1 alpha 1 subunit
Publication Statistics
PubMed Score 267.94
PubMed score by year
PubTator Score 104.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title