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Tbio
PDGFRL
Platelet-derived growth factor receptor-like protein

Protein Summary
Description
This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251630
  • ENSP00000251630
  • ENSG00000104213
  • ENST00000541323
  • ENSP00000444211

Symbol
  • PRLTS
  • PDGRL
  • PRLTS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.87
PubMedID
0.85
virus perturbation
0.76
molecular function
0.67
tissue sample
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.69   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.69   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
MOCS1
Tclin
Novelty:  0.02785369
p_int:  0.999799106
p_ni:  0.000200893
Data Source:  BioPlex
SGSM1
Tbio
Novelty:  0.27948733
p_int:  0.999776464
p_ni:  0.000221652
p_wrong:  0.000001884
Data Source:  BioPlex
IKBIP
Tbio
Family:  Enzyme
Novelty:  0.18707639
p_int:  0.999433688
p_ni:  0.000564899
p_wrong:  0.000001414
Data Source:  BioPlex
ZMYM2
Tbio
Novelty:  0.0258698
p_int:  0.998770944
p_ni:  0.001229056
Data Source:  BioPlex
RCOR2
Tbio
Family:  TF
Novelty:  0.17728151
p_int:  0.998567325
p_ni:  0.001430783
p_wrong:  0.000001892
Data Source:  BioPlex
ITIH2
Tbio
Novelty:  0.04886358
p_int:  0.997647715
p_ni:  0.002247245
p_wrong:  0.00010504
Data Source:  BioPlex
RCOR1
Tbio
Family:  TF
Novelty:  0.00644648
p_int:  0.994435849
p_ni:  0.005564151
Data Source:  BioPlex
ANKRD28
Tbio
Family:  Enzyme
Novelty:  0.10895759
p_int:  0.992401336
p_ni:  0.007598664
Data Source:  BioPlex
RCOR3
Tdark
Family:  TF
Novelty:  0.18886215
p_int:  0.990142485
p_ni:  0.009857515
Data Source:  BioPlex
SP3
Tbio
Family:  TF
Novelty:  0.00119924
p_int:  0.971842102
p_ni:  0.028109521
p_wrong:  0.000048376
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
amino acid measurement
1
3
4
80
diastolic blood pressure
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
amino acid measurement
4
80
diastolic blood pressure
1
38.8
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
platelet derived growth factor receptor like
VGNC:7740
464010
Macaque
platelet derived growth factor receptor like
703117
Mouse
MGI:1916047
68797
Rat
RGD:1308028
290771
Dog
platelet derived growth factor receptor like
VGNC:44374
607033
Species
Name
OMA
EggNOG
Inparanoid
Chimp
platelet derived growth factor receptor like
Macaque
platelet derived growth factor receptor like
Mouse
Rat
Dog
platelet derived growth factor receptor like
Publication Statistics
PubMed Score 13.69
PubMed score by year
PubTator Score 10.51
PubTator score by year
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Related Publications
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PMID
Year
Title