Tbio PDGFD Platelet-derived growth factor D

Protein Summary

Description

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity). The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9GZP0
• A8K9T6
• Q9BWV5
• PDGF-D

Gene Name

• PDGFD

Ensembl ID

• ENST00000302251
• ENSP00000302193
• ENSG00000170962
• ENST00000393158
• ENSP00000376865

Symbol

• IEGF
• SCDGFB
• IEGF
• SCDGFB
• MSTP036
• SCDGF-B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.64
phenotype	0.61
tissue sample	0.6
biological term	0.59
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Platelet-derived Growth Factor D

DTO Classes

Protein / Signaling / Growth Factor / Platelet-derived Growth Factor D

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.03   (req: < 5)

Gene RIFs: 62   (req: <= 3)

Antibodies: 257   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.03   (req: >= 5)

Gene RIFs: 62   (req: > 3)

Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0