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Tchem
PDF
Peptide deformylase, mitochondrial

Protein Summary
Description
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Protein synthesis proceeds after formylation of methionine by methionyl-tRNA formyl transferase (FMT) and transfer of the charged initiator f-met tRNA to the ribosome. In eubacteria and eukaryotic organelles the product of this gene, peptide deformylase (PDF), removes the formyl group from the initiating methionine of nascent peptides. In eubacteria, deformylation of nascent peptides is required for subsequent cleavage of initiating methionines by methionine aminopeptidase. The discovery that a natural inhibitor of PDF, actinonin, acts as an antimicrobial agent in some bacteria has spurred intensive research into the design of bacterial-specific PDF inhibitors. In human cells, only mitochondrial proteins have N-formylation of initiating methionines. Protein inhibitors of PDF or siRNAs of PDF block the growth of cancer cell lines but have no effect on normal cell growth. In humans, PDF function may therefore ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288022
  • ENSP00000288022
  • ENSG00000258429

Symbol
  • PDF1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.81
tissue
0.69
tissue sample
0.65
disease perturbation
0.62
interacting protein
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.85   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.85   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 60
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (155)
KIF1B
Tbio
Novelty:  0.00984332
p_int:  0.994599147
p_ni:  0.005400853
Score:  0.159
Data Source:  BioPlex,STRINGDB
CRP
Tbio
Novelty:  0.00001517
p_int:  0.98002951
p_ni:  0.019970488
p_wrong:  2e-9
Data Source:  BioPlex
MRPS34
Tbio
Novelty:  0.29355603
p_int:  0.959241396
p_ni:  0.0407586
p_wrong:  4e-9
Score:  0.229
Data Source:  BioPlex,STRINGDB
TMEM25
Tdark
Novelty:  0.35505784
p_int:  0.950991316
p_ni:  0.049008683
p_wrong:  1e-9
Data Source:  BioPlex
PTCH1
Tbio
Novelty:  0.00077635
p_int:  0.950049676
p_ni:  0.049950324
Data Source:  BioPlex
HFE
Tbio
Novelty:  0.00042077
p_int:  0.943412516
p_ni:  0.056578287
p_wrong:  0.000009198
Data Source:  BioPlex
P4HA3
Tbio
Family:  Enzyme
Novelty:  0.03832564
p_int:  0.930371551
p_ni:  0.069628446
p_wrong:  3e-9
Data Source:  BioPlex
GPSM3
Tbio
Novelty:  0.01632501
p_int:  0.92528471
p_ni:  0.072823341
p_wrong:  0.001891949
Data Source:  BioPlex
RNF7
Tbio
Novelty:  0.02532658
p_int:  0.921437683
p_ni:  0.078560915
p_wrong:  0.000001402
Data Source:  BioPlex
A2M
Tbio
Novelty:  0.00070446
p_int:  0.918326211
p_ni:  0.081673784
p_wrong:  5e-9
Score:  0.154
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
4
2
4
80.6
daytime rest measurement
1
1
1
55.2
telomere length
1
1
1
38.8
apolipoprotein A 1 measurement
1
1
1
35
total cholesterol measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
4
80.6
daytime rest measurement
1
55.2
telomere length
1
38.8
apolipoprotein A 1 measurement
1
35
total cholesterol measurement
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Rat
RGD:1582894
690214
Dog
peptide deformylase, mitochondrial
VGNC:49608
610955
Cow
peptide deformylase, mitochondrial
VGNC:49562
788473
Opossum
peptide deformylase, mitochondrial
100027986
Anole lizard
peptide deformylase, mitochondrial
100560353
Species
Name
OMA
EggNOG
Inparanoid
Rat
Dog
peptide deformylase, mitochondrial
Cow
peptide deformylase, mitochondrial
Opossum
peptide deformylase, mitochondrial
Anole lizard
peptide deformylase, mitochondrial
Publication Statistics
PubMed Score 35.85
PubMed score by year
PubTator Score 283.62
PubTator score by year
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Related Publications
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PMID
Year
Title