PDE9A
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Protein Summary
Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:9624146, PubMed:18757755, PubMed:21483814). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (By similarity). The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulat ...more
- ENST00000291539
- ENSP00000291539
- ENSG00000160191
- ENST00000328862
- ENSP00000328699
- ENST00000335440
- ENSP00000335365
- ENST00000335512
- ENSP00000335242
- ENST00000349112
- ENSP00000344730
- ENST00000380328
- ENSP00000369685
- ENST00000398224
- ENSP00000381280
- ENST00000398225
- ENSP00000381281
- ENST00000398227
- ENSP00000381283
- ENST00000398229
- ENSP00000381285
- ENST00000398232
- ENSP00000381287
- ENST00000398234
- ENSP00000381289
- ENST00000398236
- ENSP00000381291
- HSPDE9A2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.76 | ||
PubMedID | 0.73 | ||
disease | 0.63 | ||
transcription factor binding site profile | 0.59 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 61.11 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 207 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 61.11 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 207 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 443
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (443)
Protein-Protein Interactions (77)
UNC119
Novelty: 0.00396292
p_int: 0.999999999
p_wrong: 1e-9
Score: 0.329
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (19)
Upstream (5)
Downstream (14)
Pathways (12)
Reactome (4)
KEGG (2)
PathwayCommons (2)
UniProt (1)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Hemostasis | ||||
Reactome | Nitric oxide stimulates guanylate cyclase | ||||
Reactome | Platelet homeostasis | ||||
Reactome | cGMP effects | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Hemostasis | ||||
Nitric oxide stimulates guanylate cyclase | ||||
Platelet homeostasis | ||||
cGMP effects | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (4)
Components (7)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
hematocrit | 2 | 2 | 2 | 77.8 | |||||
hemoglobin measurement | 2 | 2 | 2 | 73.4 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
hematocrit | 2 | 77.8 | |||||
hemoglobin measurement | 2 | 73.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | phosphodiesterase 9A | VGNC:1134 | 474020 | |||||
Macaque | phosphodiesterase 9A | 100301991 | ||||||
Mouse | MGI:1277179 | 18585 | ||||||
Rat | RGD:621035 | 191569 | ||||||
Dog | phosphodiesterase 9A | VGNC:44367 | 611022 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | phosphodiesterase 9A | |||||
Macaque | phosphodiesterase 9A | |||||
Mouse | ||||||
Rat | ||||||
Dog | phosphodiesterase 9A | |||||
Publication Statistics
PubMed Score 61.11
PubMed score by year
PubTator Score 32.49
PubTator score by year
Related Publications
Text Mined References (27)
GeneRif Annotations (13)
Items per page:
0 of 0
PMID | Year | Title |
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