PDE9A
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Protein Summary
Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:9624146, PubMed:18757755, PubMed:21483814). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (By similarity). The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulat ...more
- ENST00000291539
- ENSP00000291539
- ENSG00000160191
- ENST00000328862
- ENSP00000328699
- ENST00000335440
- ENSP00000335365
- ENST00000335512
- ENSP00000335242
- ENST00000349112
- ENSP00000344730
- ENST00000380328
- ENSP00000369685
- ENST00000398224
- ENSP00000381280
- ENST00000398225
- ENSP00000381281
- ENST00000398227
- ENSP00000381283
- ENST00000398229
- ENSP00000381285
- ENST00000398232
- ENSP00000381287
- ENST00000398234
- ENSP00000381289
- ENST00000398236
- ENSP00000381291
- HSPDE9A2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.76 | ||
PubMedID | 0.73 | ||
disease | 0.63 | ||
transcription factor binding site profile | 0.59 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 71.93 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 207 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 71.93 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 207 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 443
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1