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Tclin
PDE8B
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

Protein Summary
Description
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland. The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264917
  • ENSP00000264917
  • ENSG00000113231
  • ENST00000333194
  • ENSP00000331336
  • ENST00000340978
  • ENSP00000345446
  • ENST00000342343
  • ENSP00000345646
  • ENST00000346042
  • ENSP00000330428
  • ENST00000505283
  • ENSP00000423461

Symbol
  • ADSD
  • PPNAD3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
biological process
0.87
disease perturbation
0.83
transcription factor perturbation
0.68
histone modification site profile
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.69   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.69   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 117
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (117)
CHEMBL4128481
Rendered image for CHEMBL4128481
CHEMBL2070735
Rendered image for CHEMBL2070735
CHEMBL1779976
Rendered image for CHEMBL1779976
CHEMBL1779984
Rendered image for CHEMBL1779984
CHEMBL1779978
Rendered image for CHEMBL1779978
CHEMBL1780094
Rendered image for CHEMBL1780094
CHEMBL1779987
Rendered image for CHEMBL1779987
CHEMBL2070733
Rendered image for CHEMBL2070733
CHEMBL1780096
Rendered image for CHEMBL1780096
CHEMBL2070732
Rendered image for CHEMBL2070732
Protein-Protein Interactions (83)
APRT
Tchem
Family:  Enzyme
Novelty:  0.00483077
Score:  0.922
Data Source:  STRINGDB
ADK
Tchem
Family:  Kinase
Novelty:  0.00196435
Score:  0.911
Data Source:  STRINGDB
ADSL
Tbio
Family:  Enzyme
Novelty:  0.0028496
Score:  0.91
Data Source:  STRINGDB
AK3
Tbio
Family:  Kinase
Novelty:  0.02673466
Score:  0.903
Data Source:  STRINGDB
DCK
Tchem
Family:  Kinase
Novelty:  0.00201831
Score:  0.902
Data Source:  STRINGDB
PDE8A
Tclin
Family:  Enzyme
Novelty:  0.04254335
Score:  0.804
Data Source:  STRINGDB
ADCY9
Tbio
Family:  Enzyme
Novelty:  0.00744116
Score:  0.759
Data Source:  STRINGDB
AMPD3
Tchem
Family:  Enzyme
Novelty:  0.01230806
Score:  0.757
Data Source:  STRINGDB
AMPD2
Tchem
Family:  Enzyme
Novelty:  0.01510718
Score:  0.747
Data Source:  STRINGDB
AK2
Tbio
Family:  Kinase
Novelty:  0.00581034
Score:  0.732
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (79)
G alpha (s) signalling events (R-HSA-418555)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
3
3
1.1
93.1
thyroid stimulating hormone measurement
2
3
3
91.1
thyroid function
2
2
2
89.2
testosterone measurement
3
3
5
88.8
2
2
1
1.1
87.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
93.1
thyroid stimulating hormone measurement
3
91.1
thyroid function
2
89.2
testosterone measurement
5
88.8
1
1.1
87.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 8B
VGNC:4125
461796
Macaque
phosphodiesterase 8B
712674
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 8B
Macaque
phosphodiesterase 8B
Publication Statistics
PubMed Score 36.69
PubMed score by year
PubTator Score 36.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title