PDE8B
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
Protein Summary
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland. The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
- ENST00000264917
- ENSP00000264917
- ENSG00000113231
- ENST00000333194
- ENSP00000331336
- ENST00000340978
- ENSP00000345446
- ENST00000342343
- ENSP00000345646
- ENST00000346042
- ENSP00000330428
- ENST00000505283
- ENSP00000423461
- ADSD
- PPNAD3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.92 | ||
biological process | 0.87 | ||
disease perturbation | 0.83 | ||
transcription factor perturbation | 0.68 | ||
histone modification site profile | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 48.29 (req: < 5)
Gene RIFs: 25 (req: <= 3)
Antibodies: 146 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 48.29 (req: >= 5)
Gene RIFs: 25 (req: > 3)
Antibodies: 146 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 117
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2