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Tbio
PDE4DIP
Myomegalin

Protein Summary
Description
Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity). Isoform 13: Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome (PubMed:25217626, PubMed:27666745, PubMed:28814570, PubMed:29162697). In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression (PubMed:29162697).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313431
  • ENSP00000316434
  • ENSG00000178104
  • ENST00000369347
  • ENSP00000358353
  • ENST00000369349
  • ENSP00000358355
  • ENST00000369351
  • ENSP00000358357
  • ENST00000369354
  • ENSP00000358360
  • ENST00000369356
  • ENSP00000358363
  • ENST00000529945
  • ENSP00000433392
  • ENST00000530472
  • ENSP00000482121
  • ENST00000618462
  • ENSP00000479409

Symbol
  • CMYA2
  • KIAA0454
  • KIAA0477
  • MMGL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
PubMedID
0.97
disease perturbation
0.95
kinase perturbation
0.88
transcription factor
0.87


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.92   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.92   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (98)
PM20D1
Tdark
Family:  Enzyme
Novelty:  0.07205788
p_int:  0.999999104
p_ni:  3.8e-8
p_wrong:  8.58e-7
Data Source:  BioPlex
A2ML1
Tbio
Novelty:  0.05923067
p_int:  0.999992045
p_ni:  0.000007949
p_wrong:  6e-9
Data Source:  BioPlex
MAPRE1
Tbio
Novelty:  0.01267772
p_int:  0.999991863
p_ni:  0.000008137
Score:  0.461
Data Source:  BioPlex,STRINGDB
AKAP9
Tbio
Family:  Enzyme
Novelty:  0.0106532
p_int:  0.999985171
p_ni:  0.000014828
Score:  0.923
Data Source:  BioPlex,STRINGDB
FAM129B
Tbio
Novelty:  0.15635142
p_int:  0.999979341
p_ni:  0.000020625
p_wrong:  3.5e-8
Score:  0.161
Data Source:  BioPlex,STRINGDB
CSNK1D
Tchem
Family:  Kinase
Novelty:  0.00896935
p_int:  0.999959769
p_ni:  0.000040231
Score:  0.153
Data Source:  BioPlex,STRINGDB
LCN2
Tbio
Family:  Enzyme
Novelty:  0.00034678
p_int:  0.999890552
p_ni:  0.000109448
Data Source:  BioPlex
CD207
Tbio
Novelty:  0.00313729
p_int:  0.999874966
p_ni:  0.000036523
p_wrong:  0.000088511
Score:  0.201
Data Source:  BioPlex,STRINGDB
PRKAR2B
Tchem
Family:  Enzyme
Novelty:  0.00456972
p_int:  0.999871011
p_ni:  0.000128989
Score:  0.529
Data Source:  BioPlex,STRINGDB
CSNK1E
Tclin
Family:  Kinase
Novelty:  0.00891859
p_int:  0.999870383
p_ni:  0.000129617
Score:  0.153
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Rat
RGD:708410
64183
Cow
myomegalin
508547
Opossum
phosphodiesterase 4D interacting protein
100617812
Xenopus
phosphodiesterase 4D interacting protein
XB-GENE-982015
780348
Zebrafish
ZDB-GENE-030131-1518
566905
Species
Name
OMA
EggNOG
Inparanoid
Rat
Cow
myomegalin
Opossum
phosphodiesterase 4D interacting protein
Xenopus
phosphodiesterase 4D interacting protein
Zebrafish
Publication Statistics
PubMed Score 30.92
PubMed score by year
Related Publications
No publications found