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Tclin
PDE4D
cAMP-specific 3',5'-cyclic phosphodiesterase 4D

Protein Summary
Description
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309641
  • ENSP00000308485
  • ENSG00000113448
  • ENST00000317118
  • ENSP00000321739
  • ENST00000340635
  • ENSP00000345502
  • ENST00000358923
  • ENSP00000351800
  • ENST00000360047
  • ENSP00000353152
  • ENST00000405755
  • ENSP00000384806
  • ENST00000502484
  • ENSP00000423094
  • ENST00000502575
  • ENSP00000425917
  • ENST00000503258
  • ENSP00000425605
  • ENST00000507116
  • ENSP00000424852

Symbol
  • DPDE3
  • DPDE3
  • PDE43
  • STRK1
  • ACRDYS2
  • HSPDE4D
  • PDE4DN2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
trait
1
molecular function
0.99
co-expressed gene
0.96
microRNA
0.91


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 313.91   (req: < 5)
Gene RIFs: 132   (req: <= 3)
Antibodies: 427   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 313.91   (req: >= 5)
Gene RIFs: 132   (req: > 3)
Antibodies: 427   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 659
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7