PDE4C
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Protein Summary
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
- ENST00000262805
- ENSP00000262805
- ENSG00000105650
- ENST00000447275
- ENSP00000402091
- ENST00000594465
- ENSP00000470210
- ENST00000594617
- ENSP00000469696
- DPDE1
- DPDE1
- PDE21
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.64 | ||
protein domain | 0.58 | ||
drug | 0.54 | ||
tissue sample | 0.54 | ||
cell line | 0.52 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 24.08 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 206 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 24.08 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 206 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 101
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 7