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Tclin
PDE4C
cAMP-specific 3',5'-cyclic phosphodiesterase 4C

Protein Summary
Description
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262805
  • ENSP00000262805
  • ENSG00000105650
  • ENST00000447275
  • ENSP00000402091
  • ENST00000594465
  • ENSP00000470210
  • ENST00000594617
  • ENSP00000469696

Symbol
  • DPDE1
  • DPDE1
  • PDE21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.64
protein domain
0.58
drug
0.54
tissue sample
0.54
cell line
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.77   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 206   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.77   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 93
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (74)
AK3
Tbio
Family:  Kinase
Novelty:  0.02673466
Score:  0.907
Data Source:  STRINGDB
ADK
Tchem
Family:  Kinase
Novelty:  0.00196435
Score:  0.904
Data Source:  STRINGDB
ADSL
Tbio
Family:  Enzyme
Novelty:  0.0028496
Score:  0.904
Data Source:  STRINGDB
APRT
Tchem
Family:  Enzyme
Novelty:  0.00483077
Score:  0.903
Data Source:  STRINGDB
DCK
Tchem
Family:  Kinase
Novelty:  0.00201831
Score:  0.902
Data Source:  STRINGDB
ADCY9
Tbio
Family:  Enzyme
Novelty:  0.00744116
Score:  0.85
Data Source:  STRINGDB
ADCY6
Tchem
Family:  Enzyme
Novelty:  0.00528765
Score:  0.838
Data Source:  STRINGDB
ADCY5
Tchem
Family:  Enzyme
Novelty:  0.00307839
Score:  0.838
Data Source:  STRINGDB
ADCY10
Tchem
Family:  Enzyme
Novelty:  0.00037654
Score:  0.813
Data Source:  STRINGDB
ADCY8
Tchem
Family:  Enzyme
Novelty:  0.00510386
Score:  0.807
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
DARPP-32 events (R-HSA-180024)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DARPP-32 events
Reactome
G alpha (i) signalling events
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Opioid Signalling
Name
Explore in Pharos
Explore in Source
DARPP-32 events
G alpha (i) signalling events
G alpha (s) signalling events
GPCR downstream signalling
Opioid Signalling
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (48)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
13
18
32
98.2
waist-hip ratio
5
15
17
98.1
waist circumference
1
8
8
93.8
BMI-adjusted waist circumference
3
9
10
92.7
serum alanine aminotransferase measurement
2
2
1
9.8
89.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
32
98.2
waist-hip ratio
17
98.1
waist circumference
8
93.8
BMI-adjusted waist circumference
10
92.7
serum alanine aminotransferase measurement
1
9.8
89.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 19.77
PubMed score by year
PubTator Score 18.65
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title