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Tclin
PDE4A
cAMP-specific 3',5'-cyclic phosphodiesterase 4A

Protein Summary
Description
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293683
  • ENSP00000293683
  • ENSG00000065989
  • ENST00000344979
  • ENSP00000341007
  • ENST00000380702
  • ENSP00000370078
  • ENST00000440014
  • ENSP00000394754
  • ENST00000592685
  • ENSP00000468507

Symbol
  • DPDE2
  • PDE4
  • DPDE2
  • PDE46
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.95
transcription factor binding site profile
0.93
molecular function
0.9
drug
0.79
PubMedID
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1796.08   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 408   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1796.08   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 408   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 529
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 9