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Tclin
PDE3B
cGMP-inhibited 3',5'-cyclic phosphodiesterase B

Protein Summary
Description
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282096
  • ENSP00000282096
  • ENSG00000152270
  • ENST00000455098
  • ENSP00000388644

Symbol
  • HcGIP1
  • cGIPDE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.91
microRNA
0.82
kinase perturbation
0.76
disease perturbation
0.74
PubMedID
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.23   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.23   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 82
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8