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Tclin
PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

Protein Summary
Description
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Plays an important role in growth and invasion of malignant melanoma cells (e.g. pseudomyxoma peritonei (PMP) cell line) (PubMed:24705027). Isoform PDE2A2: Regulates mitochondrial cAMP levels and respiration (By similarity). Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L (PubMed:28463107).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334456
  • ENSP00000334910
  • ENSG00000186642
  • ENST00000376450
  • ENSP00000365633
  • ENST00000444035
  • ENSP00000411657
  • ENST00000540345
  • ENSP00000446399
  • ENST00000544570
  • ENSP00000442256

Symbol
  • PDE2A1
  • PED2A4
  • cGSPDE
  • CGS-PDE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
protein domain
0.85
PubMedID
0.82
gene perturbation
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.54   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 292   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.54   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 292   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 716
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2