Tclin PDE10A cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Protein Summary

Description

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition. The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q9Y233
• Q6FHX1
• Q9HCP9
• Q9NTV4
• Q9ULW9
• Q9Y5T1

Gene Name

• PDE10A

Ensembl ID

• ENST00000366882
• ENSP00000355847
• ENSG00000112541
• ENST00000650117
• ENSP00000497426

Symbol

• ADSD2
• IOLOD
• HSPDE10A
• PDE10A19
• LINC00473

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	1
molecular function	0.94
protein domain	0.85
microRNA	0.77
PubMedID	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 392.89   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 194   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 392.89   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4152

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2