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Tbio
PDCD6
Programmed cell death protein 6

Protein Summary
Description
Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair. Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface, promoting interaction with different sets of proteins thanks to 3 different hydrophobic pockets, leading to translocation to membranes (PubMed:20691033, PubMed:25667979). Involved in ER-Golgi transport by promoting the association between PDCD6IP and TSG101, thereby bridging together the ESCRT-III and ESCRT-I complexes (PubMed:19520058). Together with PEF1, acts as calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in ER-Golgi transport by regulating the size of COPII coats (PubMed:27716508). In response to cytosolic calcium increase, the heterodimer formed with PEF1 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264933
  • ENSP00000264933
  • ENSG00000249915
  • ENST00000505221
  • ENSP00000422085
  • ENST00000507528
  • ENSP00000423815

Symbol
  • ALG2
  • ALG2
  • ALG-2
  • PEF1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.96
cellular component
0.95
kinase perturbation
0.95
co-expressed gene
0.89


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.23   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 297   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.23   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 297   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (117)
SEC31A
Tbio
Novelty:  0.0350228
Score:  0.995
Data Source:  STRINGDB
PEF1
Tbio
Novelty:  0.01442356
Score:  0.978
Data Source:  STRINGDB
SEC31B
Tdark
Novelty:  0.35742768
Score:  0.976
Data Source:  STRINGDB
SEC13
Tbio
Novelty:  0.00709413
Score:  0.957
Data Source:  STRINGDB
SEC24B
Tbio
Novelty:  0.01031644
Score:  0.939
Data Source:  STRINGDB
SEC23A
Tbio
Novelty:  0.0384262
Score:  0.936
Data Source:  STRINGDB
KLHL12
Tbio
Novelty:  0.05789229
Score:  0.928
Data Source:  STRINGDB
SEC24A
Tbio
Novelty:  0.07724534
Score:  0.923
Data Source:  STRINGDB
SAR1A
Tbio
Family:  Enzyme
Novelty:  0.0335242
Score:  0.921
Data Source:  STRINGDB
SEC24C
Tbio
Novelty:  0.05842956
Score:  0.914
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (37)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
normal
1
1
1
66.7
1
1
1
66.6
systolic blood pressure
1
1
1
50.3
BMI-adjusted hip circumference
2
4
4
47.6
hearing measurement
1
1
1
39.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
normal
1
66.7
1
66.6
systolic blood pressure
1
50.3
BMI-adjusted hip circumference
4
47.6
hearing measurement
1
39.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
programmed cell death 6
VGNC:4123
471813
Mouse
MGI:109283
18570
Rat
RGD:1311239
308061
Dog
programmed cell death 6
VGNC:44340
609549
Horse
programmed cell death 6 [Source:HGNC Symbol;Acc:HGNC:8765]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
programmed cell death 6
Mouse
Rat
Dog
programmed cell death 6
Horse
programmed cell death 6 [Source:HGNC Symbol;Acc:HGNC:8765]
Publication Statistics
PubMed Score 96.23
PubMed score by year
PubTator Score 24.86
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title