Tbio PDCD5 Programmed cell death protein 5

Protein Summary

Description

May function in the process of apoptosis. This gene encodes a protein that is upregulated during apoptosis where it translocates rapidly from the cytoplasm to the nucleus. The encoded protein may be an important regulator of K(lysine) acetyltransferase 5 (a protein involved in transcription, DNA damage response and cell cycle control) by inhibiting its proteasome-dependent degradation. Pseudogenes have been identified on chromosomes 5 and 12 [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• O14737
• B4DE64
• Q53YC9
• Q6IB70

Gene Name

• PDCD5

Ensembl ID

• ENST00000419343
• ENSP00000476525
• ENSG00000105185
• ENST00000590247
• ENSP00000466214

Symbol

• TFAR19
• TFAR19

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.79
gene perturbation	0.78
biological process	0.77
histone modification site profile	0.75
hub protein	0.75

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Programmed Cell Death Protein 5

DTO Classes

Protein / Enzyme Modulator / Programmed Cell Death Protein 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.22   (req: < 5)

Gene RIFs: 60   (req: <= 3)

Antibodies: 226   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.22   (req: >= 5)

Gene RIFs: 60   (req: > 3)

Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0