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Tchem
PDCD4
Programmed cell death protein 4

Protein Summary
Description
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280154
  • ENSP00000280154
  • ENSG00000150593
  • ENST00000393104
  • ENSP00000376816

Symbol
  • H731
  • H731
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
kinase perturbation
0.93
disease perturbation
0.9
gene perturbation
0.89
drug perturbation
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 575.7   (req: < 5)
Gene RIFs: 202   (req: <= 3)
Antibodies: 751   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 575.7   (req: >= 5)
Gene RIFs: 202   (req: > 3)
Antibodies: 751   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (133)
EIF4A1
Tchem
Novelty:  0.00269994
p_int:  0.999999893
p_ni:  8.9e-8
p_wrong:  1.8e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
BTRC
Tbio
Novelty:  0.00293475
p_int:  0.999999208
p_ni:  7.58e-7
p_wrong:  3.4e-8
Score:  0.603
Data Source:  BioPlex,STRINGDB
TMEM51
Tdark
Novelty:  0.54147214
p_int:  0.999978597
p_ni:  0.000021397
p_wrong:  6e-9
Score:  0.213
Data Source:  BioPlex,STRINGDB
TGIF2LY
Tdark
Family:  TF
p_int:  0.999899173
p_ni:  0.000038658
p_wrong:  0.00006217
Data Source:  BioPlex
COMTD1
Tdark
Family:  Enzyme
Novelty:  0.245971
p_int:  0.997047135
p_ni:  0.000802889
p_wrong:  0.002149976
Score:  0.181
Data Source:  BioPlex,STRINGDB
RPS6KB1
Tchem
Family:  Kinase
Novelty:  0.00044681
Score:  0.974
Data Source:  STRINGDB
EIF4A2
Tbio
Novelty:  0.00298045
Score:  0.97
Data Source:  STRINGDB
EIF4G1
Tbio
Novelty:  0.00170995
Score:  0.955
Data Source:  STRINGDB
STAT4
Tchem
Family:  TF
Novelty:  0.00251747
Score:  0.906
Data Source:  STRINGDB
GMPS
Tbio
Family:  Enzyme
Novelty:  0.00611806
Score:  0.844
Data Source:  STRINGDB
Pathways (348)
Cytokine Signaling in Immune system (R-HSA-1280215)

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1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Reactome
Immune System
Reactome
Interleukin-12 family signaling
Reactome
Interleukin-12 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Immune System
Interleukin-12 family signaling
Interleukin-12 signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
1
6
75.4
3
2
2
1.1
71.1
1
1
0
1.1
24.5
diet measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
6
75.4
2
1.1
71.1
0
1.1
24.5
diet measurement
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
programmed cell death 4
695345
Mouse
MGI:107490
18569
Rat
RGD:620816
64031
Dog
programmed cell death 4
VGNC:44338
477818
Horse
programmed cell death 4
VGNC:21231
100059302
Species
Name
OMA
EggNOG
Inparanoid
Macaque
programmed cell death 4
Mouse
Rat
Dog
programmed cell death 4
Horse
programmed cell death 4
Publication Statistics
PubMed Score 575.70
PubMed score by year
PubTator Score 235.09
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title