Tchem PDCD4 Programmed cell death protein 4

Protein Summary

Description

Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• Q53EL6
• B2RCV4
• B5ME91
• O15501
• Q5VZS6
• Q6PJI5
• Q8TAR5
• Q99834

Gene Name

• PDCD4

Ensembl ID

• ENST00000280154
• ENSP00000280154
• ENSG00000150593
• ENST00000393104
• ENSP00000376816

Symbol

• H731
• H731

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
kinase perturbation	0.93
disease perturbation	0.9
gene perturbation	0.89
drug perturbation	0.87

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Elongation Factor / Programmed Cell Death Protein 4

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Elongation Factor / Programmed Cell Death Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 614.73   (req: < 5)

Gene RIFs: 260   (req: <= 3)

Antibodies: 751   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 614.73   (req: >= 5)

Gene RIFs: 260   (req: > 3)

Antibodies: 751   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1