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Tbio
PDCD2L
Programmed cell death protein 2-like

Protein Summary
Description
Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246535
  • ENSP00000246535
  • ENSG00000126249
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
virus perturbation
0.97
histone modification site profile
0.87
disease perturbation
0.83
transcription factor perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.46   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.46   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
RPS2
Tbio
Novelty:  0.00412313
p_int:  0.999999989
p_ni:  1.1e-8
Score:  0.807
Data Source:  BioPlex,STRINGDB
PRMT3
Tchem
Family:  Epigenetic
Novelty:  0.03433797
p_int:  0.999996769
p_ni:  1.1e-8
p_wrong:  0.00000322
Score:  0.892
Data Source:  BioPlex,STRINGDB
GRAMD1B
Tbio
Novelty:  0.2994102
p_int:  0.999820206
p_ni:  0.00017979
p_wrong:  5e-9
Data Source:  BioPlex
NAP1L5
Tbio
Novelty:  0.10378595
p_int:  0.999559891
p_ni:  0.000440109
Score:  0.549
Data Source:  BioPlex,STRINGDB
EIF5A2
Tbio
Novelty:  0.01527502
p_int:  0.997776459
p_ni:  0.002212471
p_wrong:  0.00001107
Data Source:  BioPlex
PCBP3
Tbio
Novelty:  0.11681812
p_int:  0.996049605
p_ni:  0.003863022
p_wrong:  0.000087373
Score:  0.183
Data Source:  BioPlex,STRINGDB
SLX4IP
Tbio
Novelty:  0.25359409
p_int:  0.991243006
p_ni:  0.008579311
p_wrong:  0.000177683
Score:  0.211
Data Source:  BioPlex,STRINGDB
EIF1AD
Tdark
Novelty:  0.23915521
p_int:  0.990319777
p_ni:  0.009674304
p_wrong:  0.000005919
Data Source:  BioPlex
XXYLT1
Tbio
Family:  Enzyme
Novelty:  0.16837376
p_int:  0.973628019
p_ni:  0.026371883
p_wrong:  9.7e-8
Data Source:  BioPlex
ARIH1
Tbio
Family:  Enzyme
Novelty:  0.0258739
p_int:  0.972857468
p_ni:  0.027076921
p_wrong:  0.000065611
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
15.8
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
programmed cell death 2 like
VGNC:13303
744693
Macaque
programmed cell death 2 like
705688
Mouse
MGI:1915329
68079
Rat
RGD:1589941
689637
Dog
programmed cell death 2 like
VGNC:53750
484594
Species
Name
OMA
EggNOG
Inparanoid
Chimp
programmed cell death 2 like
Macaque
programmed cell death 2 like
Mouse
Rat
Dog
programmed cell death 2 like
Publication Statistics
PubMed Score 3.46
PubMed score by year
PubTator Score 1.25
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title