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Tbio
PDCD2
Programmed cell death protein 2

Protein Summary
Description
May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation. This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392090
  • ENSP00000375940
  • ENSG00000071994
  • ENST00000443345
  • ENSP00000397272
  • ENST00000453163
  • ENSP00000402524
  • ENST00000537445
  • ENSP00000440572
  • ENST00000541970
  • ENSP00000439467

Symbol
  • RP8
  • ZMYND7
  • RP8
  • ZMYND7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
disease perturbation
0.9
histone modification site profile
0.88
kinase perturbation
0.84
transcription factor perturbation
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.28   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.28   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0