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Tchem
PDCD1LG2
Programmed cell death 1 ligand 2

Protein Summary
Description
Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397747
  • ENSP00000380855
  • ENSG00000197646

Symbol
  • B7DC
  • CD273
  • PDCD1L2
  • PDL2
  • B7DC
  • Btdc
  • PDL2
  • CD273
  • PD-L2
  • PDCD1L2
  • bA574F11.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.89
cell type or tissue
0.7
biological term
0.59
microRNA
0.59
kinase perturbation
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 558.99   (req: < 5)
Gene RIFs: 82   (req: <= 3)
Antibodies: 859   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 558.99   (req: >= 5)
Gene RIFs: 82   (req: > 3)
Antibodies: 859   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (137)
PDCD1
Tclin
Novelty:  0.000448
Score:  0.998
Data Source:  Reactome,STRINGDB
CD274
Tclin
Novelty:  0.00013449
Score:  0.959
Data Source:  STRINGDB
PTPN11
Tchem
Family:  Enzyme
Novelty:  0.00073124
Score:  0.955
Data Source:  Reactome,STRINGDB
CD4
Tclin
Novelty:  0.00001217
Score:  0.934
Data Source:  STRINGDB
CD3E
Tclin
Novelty:  0.0053855
Score:  0.925
Data Source:  STRINGDB
LCK
Tclin
Family:  Kinase
Novelty:  0.00058377
Score:  0.923
Data Source:  Reactome,STRINGDB
HLA-DQB2
Tbio
Novelty:  0.07062006
Score:  0.918
Data Source:  STRINGDB
HLA-DRA
Tbio
Novelty:  0.0060214
Score:  0.917
Data Source:  STRINGDB
HLA-DQA1
Tbio
Novelty:  0.00077488
Score:  0.915
Data Source:  STRINGDB
HLA-DQB1
Tbio
Novelty:  0.00197952
Score:  0.915
Data Source:  STRINGDB
Pathways (16)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Costimulation by the CD28 family
Reactome
Immune System
Reactome
PD-1 signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Costimulation by the CD28 family
Immune System
PD-1 signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
4
4
89.9
programmed cell death 1 ligand 2 measurement
1
1
1
80
alkaline phosphatase measurement
1
1
0
11.8
70.8
sex hormone-binding globulin measurement
4
1
4
64.4
balding measurement
1
1
1
44.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
4
89.9
programmed cell death 1 ligand 2 measurement
1
80
alkaline phosphatase measurement
0
11.8
70.8
sex hormone-binding globulin measurement
4
64.4
balding measurement
1
44.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
programmed cell death 1 ligand 2
VGNC:13934
737211
Macaque
programmed cell death 1 ligand 2
716003
Mouse
MGI:1930125
58205
Rat
RGD:1306403
309304
Dog
programmed cell death 1 ligand 2
VGNC:44336
609699
Species
Name
OMA
EggNOG
Inparanoid
Chimp
programmed cell death 1 ligand 2
Macaque
programmed cell death 1 ligand 2
Mouse
Rat
Dog
programmed cell death 1 ligand 2
Publication Statistics
PubMed Score 558.99
PubMed score by year
PubTator Score 201.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title