Tbio PDCD10 Programmed cell death protein 10

Protein Summary

Description

Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity (PubMed:27807006). Important for cell migration, and for normal structure and assembly of the Golgi complex (PubMed:27807006). Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9BUL8
• A8K515
• D3DNN5
• O14811

Gene Name

• PDCD10

Ensembl ID

• ENST00000392750
• ENSP00000376506
• ENSG00000114209
• ENST00000461494
• ENSP00000420021
• ENST00000470131
• ENSP00000417202
• ENST00000473645
• ENSP00000418317
• ENST00000497056
• ENSP00000420553

Symbol

• CCM3
• TFAR15
• CCM3
• TFAR15

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.97
virus perturbation	0.97
interacting protein	0.96
protein complex	0.95
histone modification site profile	0.84

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.98   (req: < 5)

Gene RIFs: 77   (req: <= 3)

Antibodies: 241   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.98   (req: >= 5)

Gene RIFs: 77   (req: > 3)

Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0