Tclin PDCD1 Programmed cell death protein 1

Protein Summary

Description

Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors. This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15116
• O00517
• Q8IX89
• Protein PD-1

Gene Name

• PDCD1

Ensembl ID

• ENST00000334409
• ENSP00000335062
• ENSG00000188389
• ENST00000618185
• ENSP00000480684
• ENSG00000276977

Symbol

• PD1
• PD1
• PD-1
• CD279
• SLEB2
• hPD-1
• hPD-l
• hSLE1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
phenotype	0.83
disease	0.68
tissue sample	0.67
hub protein	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3911.68   (req: < 5)

Gene RIFs: 1173   (req: <= 3)

Antibodies: 1947   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3911.68   (req: >= 5)

Gene RIFs: 1173   (req: > 3)

Antibodies: 1947   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4