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Tbio
PDC
Phosducin

Protein Summary
Description
May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Inhibits the transcriptional activation activity of the cone-rod homeobox CRX. This gene encodes a phosphoprotein, which is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000391997
  • ENSP00000375855
  • ENSG00000116703
  • ENST00000497198
  • ENSP00000422775

Symbol
  • PHD
  • MEKA
  • PhLP
  • PhLOP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.73
cellular component
0.66
kinase perturbation
0.6
protein domain
0.58
tissue
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 322.13   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 322.13   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
PSMC5
Tbio
Family:  Enzyme
Novelty:  0.01634039
Score:  0.904
Data Source:  STRINGDB
GNGT1
Tbio
Novelty:  0.05291961
Score:  0.869
Data Source:  STRINGDB
GNB1
Tbio
Novelty:  0.02477955
Score:  0.858
Data Source:  STRINGDB
GNAT1
Tbio
Novelty:  0.03042002
Score:  0.837
Data Source:  STRINGDB
GNAT2
Tbio
Novelty:  0.01683655
Score:  0.834
Data Source:  STRINGDB
GRK2
Tchem
Family:  Kinase
Novelty:  0.00200696
Score:  0.827
Data Source:  STRINGDB
GNAT3
Tbio
Novelty:  0.00702357
Score:  0.809
Data Source:  STRINGDB
GNB3
Tbio
Novelty:  0.0037117
Score:  0.789
Data Source:  STRINGDB
GNB4
Tbio
Novelty:  0.08250797
Score:  0.783
Data Source:  STRINGDB
GRK1
Tchem
Family:  Kinase
Novelty:  0.00598725
Score:  0.775
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:98090
20028
Rat
RGD:3277
25343
Dog
phosducin
VGNC:44333
403624
Horse
phosducin
VGNC:50858
100033898
Cow
phosducin
VGNC:32656
287007
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
phosducin
Horse
phosducin
Cow
phosducin
Publication Statistics
PubMed Score 322.13
PubMed score by year
PubTator Score 109.79
PubTator score by year
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Related Publications
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PMID
Year
Title