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Tchem
PCYT1A
Choline-phosphate cytidylyltransferase A

Protein Summary
Description
Controls phosphatidylcholine synthesis. This gene belongs to the cytidylyltransferase family and is involved in the regulation of phosphatidylcholine biosynthesis. Mutations in this gene are associated with spondylometaphyseal dysplasia with cone-rod dystrophy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292823
  • ENSP00000292823
  • ENSG00000161217
  • ENST00000431016
  • ENSP00000394617

Symbol
  • CTPCT
  • PCYT1
  • CT
  • CTA
  • CCTA
  • CTPCT
  • PCYT1
  • SMDCRD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.99
metabolite
0.97
disease perturbation
0.9
transcription factor perturbation
0.88
kinase perturbation
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.06   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 211   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.06   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (94)
CEP170
Tbio
Novelty:  0.05342931
p_int:  0.999998741
p_ni:  0.000001259
Score:  0.181
Data Source:  BioPlex,STRINGDB
SPG11
Tbio
Novelty:  0.00697875
p_int:  0.999997703
p_ni:  0.000002297
Data Source:  BioPlex
GPRC5C
Tbio
Family:  GPCR
Novelty:  0.16942353
p_int:  0.999985555
p_ni:  0.000014445
Score:  0.181
Data Source:  BioPlex,STRINGDB
IP6K3
Tbio
Family:  Kinase
Novelty:  0.13072912
p_int:  0.999972058
p_ni:  0.000027942
Score:  0.345
Data Source:  BioPlex,STRINGDB
NMNAT1
Tbio
Family:  Enzyme
Novelty:  0.01110899
p_int:  0.999842116
p_ni:  0.000157884
Score:  0.594
Data Source:  BioPlex,STRINGDB
TMEM206
Tdark
Novelty:  0.17311172
p_int:  0.997779241
p_ni:  0.002220759
Data Source:  BioPlex
LSM3
Tbio
Novelty:  0.05044984
p_int:  0.989667072
p_ni:  0.010327405
p_wrong:  0.000005523
Data Source:  BioPlex
STX11
Tbio
Novelty:  0.01670743
p_int:  0.948850768
p_ni:  0.051059622
p_wrong:  0.00008961
Score:  0.17
Data Source:  BioPlex,STRINGDB
CEPT1
Tchem
Family:  Enzyme
Novelty:  0.01816476
Score:  0.978
Data Source:  STRINGDB
CHPT1
Tbio
Family:  Enzyme
Novelty:  0.02875977
Score:  0.976
Data Source:  STRINGDB
Pathways (18)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PC
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PC
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
4
4
4
96.1
mean corpuscular volume
3
4
4
94.4
red blood cell distribution width
2
3
3
91.8
mean corpuscular hemoglobin
2
2
2
82.9
mean platelet volume
2
2
2
81.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
4
96.1
mean corpuscular volume
4
94.4
red blood cell distribution width
3
91.8
mean corpuscular hemoglobin
2
82.9
mean platelet volume
2
81.4
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IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:88557
13026
Rat
RGD:70515
140544
Dog
phosphate cytidylyltransferase 1, choline, alpha
VGNC:44329
478600
Horse
phosphate cytidylyltransferase 1, choline, alpha
VGNC:21222
100060318
Cow
phosphate cytidylyltransferase 1, choline, alpha
VGNC:32652
100125779
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
phosphate cytidylyltransferase 1, choline, alpha
Horse
phosphate cytidylyltransferase 1, choline, alpha
Cow
phosphate cytidylyltransferase 1, choline, alpha
Publication Statistics
PubMed Score 168.06
PubMed score by year
PubTator Score 44.36
PubTator score by year
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Related Publications
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PMID
Year
Title