Tchem PCYT1A Choline-phosphate cytidylyltransferase A

Protein Summary

Description

Controls phosphatidylcholine synthesis. This gene belongs to the cytidylyltransferase family and is involved in the regulation of phosphatidylcholine biosynthesis. Mutations in this gene are associated with spondylometaphyseal dysplasia with cone-rod dystrophy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2015]

Uniprot Accession IDs

• P49585
• A9LYK9
• D3DXB1
• Q86Y88

Gene Name

• PCYT1A

Ensembl ID

• ENST00000292823
• ENSP00000292823
• ENSG00000161217
• ENST00000431016
• ENSP00000394617

Symbol

• CTPCT
• PCYT1
• CT
• CTA
• CCTA
• CTPCT
• PCYT1
• SMDCRD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein) perturbation	0.99
metabolite	0.97
disease perturbation	0.9
transcription factor perturbation	0.88
kinase perturbation	0.84

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 438.35   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 211   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 438.35   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1