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Tbio
PCYOX1
Prenylcysteine oxidase 1

Protein Summary
Description
Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine. Prenylcysteine is released during the degradation of prenylated proteins. PCYOX1 catalyzes the degradation of prenylcysteine to yield free cysteines and a hydrophobic isoprenoid product (Tschantz et al., 1999 [PubMed 10585463]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000433351
  • ENSP00000387654
  • ENSG00000116005

Symbol
  • KIAA0908
  • PCL1
  • PCL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
transcription factor perturbation
0.94
molecular function
0.93
interacting protein
0.91
kinase perturbation
0.91


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.55   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.55   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (85)
ENTPD4
Tbio
Family:  Enzyme
Novelty:  0.11023026
p_int:  0.999918611
p_ni:  0.000081389
Score:  0.188
Data Source:  BioPlex,STRINGDB
BLVRA
Tbio
Family:  Enzyme
Novelty:  0.00526407
p_int:  0.99986797
p_ni:  0.00013203
Score:  0.197
Data Source:  BioPlex,STRINGDB
APOC3
Tclin
Novelty:  0.0009635
p_int:  0.999300251
p_ni:  0.000699749
Score:  0.791
Data Source:  BioPlex,STRINGDB
DYNC2LI1
Tbio
Novelty:  0.05087433
p_int:  0.998440629
p_ni:  0.001559371
Score:  0.206
Data Source:  BioPlex,STRINGDB
FDPS
Tclin
Family:  Enzyme
Novelty:  0.00164195
p_int:  0.996506739
p_ni:  0.003493261
Score:  0.278
Data Source:  BioPlex,STRINGDB
APOA2
Tbio
Novelty:  0.00117627
p_int:  0.989297307
p_ni:  0.010702693
Score:  0.786
Data Source:  BioPlex,STRINGDB
RHOBTB3
Tbio
Novelty:  0.09149494
p_int:  0.976604341
p_ni:  0.023395659
Score:  0.253
Data Source:  BioPlex,STRINGDB
TRDN
Tbio
Novelty:  0.00501554
p_int:  0.97104607
p_ni:  0.02895393
Data Source:  BioPlex
SCGB2A1
Tbio
Novelty:  0.01902973
p_int:  0.953696941
p_ni:  0.046303059
Data Source:  BioPlex
CD226
Tbio
Novelty:  0.00374102
p_int:  0.940562394
p_ni:  0.059437606
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
9
2
8
8.6
90
blood protein measurement
2
2
3
87.3
chronotype measurement
2
1
1
1
72.5
total cholesterol measurement
3
3
3
70.4
mean corpuscular volume
1
1
1
69.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
8
8.6
90
blood protein measurement
3
87.3
chronotype measurement
1
1
72.5
total cholesterol measurement
3
70.4
mean corpuscular volume
1
69.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prenylcysteine oxidase 1
VGNC:332
470398
Macaque
prenylcysteine oxidase 1
710068
Mouse
MGI:1914131
66881
Rat
RGD:628652
246302
Dog
prenylcysteine oxidase 1
VGNC:44327
481418
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prenylcysteine oxidase 1
Macaque
prenylcysteine oxidase 1
Mouse
Rat
Dog
prenylcysteine oxidase 1
Publication Statistics
PubMed Score 7.55
PubMed score by year
PubTator Score 7.54
PubTator score by year
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Related Publications
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PMID
Year
Title