You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
PCSK2
Neuroendocrine convertase 2

Protein Summary
Description
Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells. This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The protein undergoes an initial autocatalytic processing event and interacts with a neuroendocrine secretory protein in the ER, exits the ER and sorts to secretory granules, where it is cleaved and catalytically activated during intracellular transport. The encoded protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic acti ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262545
  • ENSP00000262545
  • ENSG00000125851
  • ENST00000377899
  • ENSP00000367131
  • ENST00000536609
  • ENSP00000437458

Symbol
  • NEC2
  • PC2
  • NEC2
  • SPC2
  • NEC 2
  • NEC-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
trait
0.86
PubMedID
0.76
cellular component
0.75
phenotype
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.72   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.72   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (77)
SCG5
Tbio
Novelty:  0.00379377
Score:  0.994
Data Source:  STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.955
Data Source:  Reactome,STRINGDB
CPE
Tbio
Family:  Enzyme
Novelty:  0.00197792
Score:  0.917
Data Source:  STRINGDB
SYT4
Tbio
Novelty:  0.01527865
Score:  0.865
Data Source:  STRINGDB
SYT11
Tbio
Novelty:  0.02472551
Score:  0.783
Data Source:  STRINGDB
THBD
Tbio
Novelty:  0.00039359
Score:  0.753
Data Source:  STRINGDB
CPZ
Tbio
Family:  Enzyme
Novelty:  0.00100967
Score:  0.71
Data Source:  STRINGDB
CPN1
Tchem
Family:  Enzyme
Novelty:  0.00331889
Score:  0.71
Data Source:  STRINGDB
IAPP
Tbio
Novelty:  0.0005195
Score:  0.689
Data Source:  STRINGDB
CHGA
Tbio
Novelty:  0.00033267
Score:  0.662
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Insulin processing (R-HSA-264876)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Insulin processing
Reactome
Metabolism of proteins
Reactome
Peptide hormone metabolism
Name
Explore in Pharos
Explore in Source
Insulin processing
Metabolism of proteins
Peptide hormone metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
1
1
1
65.5
wellbeing measurement
2
1
2
24.5
self reported educational attainment
1
1
1
24.5
comparative body size at age 10, self-reported
1
1
1
12
age at menarche
2
1
1
2.1
11.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
65.5
wellbeing measurement
2
24.5
self reported educational attainment
1
24.5
comparative body size at age 10, self-reported
1
12
age at menarche
1
2.1
11.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proprotein convertase subtilisin/kexin type 2
VGNC:9940
458106
Macaque
proprotein convertase subtilisin/kexin type 2
695730
Mouse
MGI:97512
18549
Rat
RGD:3273
25121
Dog
proprotein convertase subtilisin/kexin type 2
VGNC:44322
485757
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proprotein convertase subtilisin/kexin type 2
Macaque
proprotein convertase subtilisin/kexin type 2
Mouse
Rat
Dog
proprotein convertase subtilisin/kexin type 2
Publication Statistics
PubMed Score 169.72
PubMed score by year
PubTator Score 135.98
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title