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Tbio
PCSK1N
ProSAAS

Protein Summary
Description
May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known (By similarity). The protein encoded by this gene functions as an inhibitor of prohormone convertase 1, which regulates the proteolytic cleavage of neuroendocrine peptide precursors. The proprotein is further processed into multiple short peptides. A polymorphism within this gene may be associated with ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000218230
  • ENSP00000218230
  • ENSG00000102109

Symbol
  • PEN
  • SAAS
  • SCG8
  • BigLEN
  • SgVIII
  • PROSAAS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.9
cellular component
0.68
PubMedID
0.55
biological process
0.51
cell type or tissue
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.76   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.76   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
ADCYAP1
Tbio
Family:  Enzyme
Novelty:  0.00080219
p_int:  0.999991805
p_ni:  0.000008167
p_wrong:  2.8e-8
Score:  0.374
Data Source:  BioPlex,STRINGDB
CHST13
Tbio
Family:  Enzyme
Novelty:  0.15000853
p_int:  0.999930907
p_ni:  0.000065297
p_wrong:  0.000003796
Data Source:  BioPlex
ADAM21
Tdark
Family:  Enzyme
Novelty:  0.16068055
p_int:  0.999929937
p_ni:  0.000050964
p_wrong:  0.000019098
Score:  0.167
Data Source:  BioPlex,STRINGDB
MGAT4C
Tbio
Family:  Enzyme
Novelty:  0.19680806
p_int:  0.999928258
p_ni:  0.000069229
p_wrong:  0.000002513
Score:  0.179
Data Source:  BioPlex,STRINGDB
DKKL1
Tbio
Novelty:  0.00544618
p_int:  0.99985662
p_ni:  0.000026439
p_wrong:  0.00011694
Data Source:  BioPlex
MMP10
Tchem
Novelty:  0.00112113
p_int:  0.999437724
p_ni:  0.000011532
p_wrong:  0.000550745
Score:  0.187
Data Source:  BioPlex,STRINGDB
PLA2G3
Tbio
Family:  Enzyme
Novelty:  0.08997677
p_int:  0.977451911
p_ni:  0.002980932
p_wrong:  0.019567157
Data Source:  BioPlex
BST1
Tbio
Family:  Enzyme
Novelty:  0.01329061
p_int:  0.954832278
p_ni:  0.000096695
p_wrong:  0.045071027
Data Source:  BioPlex
B3GALT5
Tbio
Family:  Enzyme
Novelty:  0.04158039
p_int:  0.954832278
p_ni:  0.000096695
p_wrong:  0.045071027
Data Source:  BioPlex
SAA1
Tbio
Novelty:  0.0006102
Score:  0.831
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
2
3
80.5
eosinophil percentage of leukocytes
1
1
1
73.2
type 2 diabetes mellitus
2
2
1
1.1
63.3
platelet count
1
1
1
47.2
diastolic blood pressure
1
1
1
15.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
80.5
eosinophil percentage of leukocytes
1
73.2
type 2 diabetes mellitus
1
1.1
63.3
platelet count
1
47.2
diastolic blood pressure
1
15.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
proprotein convertase subtilisin/kexin type 1 inhibitor
714789
Mouse
MGI:1353431
30052
Rat
RGD:3617
246333
Dog
proprotein convertase subtilisin/kexin type 1 inhibitor
VGNC:44321
491870
Cow
proprotein convertase subtilisin/kexin type 1 inhibitor
VGNC:32647
513603
Species
Name
OMA
EggNOG
Inparanoid
Macaque
proprotein convertase subtilisin/kexin type 1 inhibitor
Mouse
Rat
Dog
proprotein convertase subtilisin/kexin type 1 inhibitor
Cow
proprotein convertase subtilisin/kexin type 1 inhibitor
Publication Statistics
PubMed Score 57.76
PubMed score by year
PubTator Score 1915.46
PubTator score by year
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Related Publications
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PMID
Year
Title