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Tchem
PCSK1
Neuroendocrine convertase 1

Protein Summary
Description
Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP. This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activatio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311106
  • ENSP00000308024
  • ENSG00000175426
  • ENST00000508626
  • ENSP00000421600

Symbol
  • NEC1
  • PC1
  • PC3
  • NEC1
  • SPC3
  • BMIQ12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
biological term
0.62
cell type or tissue
0.62
gene perturbation
0.61
cellular component
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 321.36   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 321.36   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (110)
ACADSB
Tbio
Family:  Enzyme
Novelty:  0.02897344
p_int:  0.979309494
p_ni:  0.020690506
Data Source:  BioPlex
HS6ST1
Tbio
Family:  Enzyme
Novelty:  0.01352454
p_int:  0.929696001
p_ni:  0.069005751
p_wrong:  0.001298247
Score:  0.287
Data Source:  BioPlex,STRINGDB
ABCB6
Tbio
Family:  Transporter
Novelty:  0.00552057
p_int:  0.870633136
p_ni:  0.129366815
p_wrong:  4.9e-8
Data Source:  BioPlex
DCAF6
Tbio
Novelty:  0.01269552
p_int:  0.859134647
p_ni:  0.140865353
Data Source:  BioPlex
B4GALT6
Tbio
Family:  Enzyme
Novelty:  0.08523889
p_int:  0.775073541
p_ni:  0.001340921
p_wrong:  0.223585539
Data Source:  BioPlex
POMC
Tbio
Novelty:  0.00002436
Score:  0.965
Data Source:  Reactome,STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.957
Data Source:  Reactome,STRINGDB
GCG
Tchem
Novelty:  0.00004879
Score:  0.955
Data Source:  STRINGDB
GIP
Tbio
Novelty:  0.0007219
Score:  0.928
Data Source:  Reactome,STRINGDB
RIPK3
Tchem
Family:  Kinase
Novelty:  0.00326006
Score:  0.809
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Incretin synthesis, secretion, and inactivation (R-HSA-400508)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Incretin synthesis, secretion, and inactivation
Reactome
Insulin processing
Reactome
Metabolism of proteins
Reactome
Peptide hormone biosynthesis
Reactome
Peptide hormone metabolism
Name
Explore in Pharos
Explore in Source
Incretin synthesis, secretion, and inactivation
Insulin processing
Metabolism of proteins
Peptide hormone biosynthesis
Peptide hormone metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
10
7
12
3.8
93.4
fasting blood glucose measurement
2
2
2
63.6
C-peptide measurement
1
1
1
63.4
glucose tolerance test
1
1
1
63.4
2
2
1
1
38.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
12
3.8
93.4
fasting blood glucose measurement
2
63.6
C-peptide measurement
1
63.4
glucose tolerance test
1
63.4
1
1
38.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proprotein convertase subtilisin/kexin type 1
VGNC:4121
461740
Macaque
proprotein convertase subtilisin/kexin type 1
699742
Mouse
MGI:97511
18548
Rat
RGD:3272
25204
Dog
proprotein convertase subtilisin/kexin type 1
VGNC:44320
479149
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proprotein convertase subtilisin/kexin type 1
Macaque
proprotein convertase subtilisin/kexin type 1
Mouse
Rat
Dog
proprotein convertase subtilisin/kexin type 1
Publication Statistics
PubMed Score 321.36
PubMed score by year
PubTator Score 852.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title